Prognostic significance of Borrmann type combined with vessel invasion status in advanced gastric cancer

Table 1 Correlation analysis of clinicopathological characteristics and lymphatic and/or blood vessel invasion (LBVI) in advanced gastric cancer

Variable	LVBI		χ2	P value
	Presence	Absence
Gender			0.011	0.916
Male	330 (74.7)	1609 (74.5)
Female	112 (25.3)	553 (25.5)
Age (yr)			2.200	0.138
< 60	233 (52.7)	1056 (48.8)
≥ 60	209 (47.3)	1106 (51.2)
Borrmann type			17.294	0.001
I	17 (3.8)	106 (4.9)
II	95 (21.5)	369 (17.1)
III	250 (56.6)	1413 (65.4)
IV	80 (18.1)	274 (12.7)
Tumor location			33.630	< 0.001
Upper third	28 (6.3)	273 (12.6)
Middle third	62 (14.0)	339 (15.7)
Lower third	220 (49.8)	1135 (52.5)
Whole stomach	132 (29.9)	415 (19.2)
Tumor size (mm)			16.077	< 0.001
< 50	118 (26.7)	793 (36.7)
≥ 50	324 (73.3)	1369 (63.3)
Histologic grade			15.084	< 0.001
Well	129 (29.2)	843 (39.0)
Poor	313 (70.8)	1319 (61.0)
pT category			213.269	< 0.001
T2	29 (6.6)	294 (13.6)
T3	212 (48.0)	358 (16.6)
T4a	171 (38.7)	1269 (58.7)
T4b	30 (6.8)	241 (11.1)
pN category			96.976	< 0.001
N0	44 (10.0)	522 (24.1)
N1	57 (12.9)	409 (18.9)
N2	95 (21.5)	529 (24.5)
N3	246 (55.7)	702 (32.5)
Surgical approach			37.183	< 0.001
Proximal gastrectomy	23 (5.2)	211 (9.8)
Distal gastrectomy	235 (53.2)	1351 (62.5)
Total gastrectomy	184 (41.6)	600 (27.8)
Combined resection			1.251	0.263
Presence	19 (4.3)	70 (3.2)
Absence	423 (95.7)	2092 (96.8)

Table 2 Clinicopathological characteristics and survival of 2604 patients with advanced gastric cancer

Variable	Patient number, n (%)	Survival period	P value
Gender			0.619
Male	1939 (74.4)	34
Female	665 (25.6)	32
Age (yr)			0.705
< 60	1289 (49.6)	34
≥ 60	1314 (50.4)	32
Lymphatic and/or blood vessel invasion			< 0.001
Presence	442 (17)	24
Absence	2162 (83)	36
Borrmann type			< 0.001
I	123 (4.7)	60
II	464 (17.8)	45
III	1663 (63.9)	34
IV	354 (13.6)	16
Tumor location			< 0.001
Upper third	301 (11.6)	32
Middle third	401 (15.4)	33
Lower third	1355 (52)	39
Whole stomach	547 (21)	22
Tumor size (mm)			< 0.001
< 50	911 (35)	45
≥ 50	1693 (65)	25
Histologic grade			< 0.001
Well	972 (37.3)	40
Poor	1632 (62.7)	30
pT category			< 0.001
T2	323 (12.4)	60
T3	570 (21.9)	37
T4a	1440 (51.3)	30
T4b	271 (10.4)	18
pN category			< 0.001
N0	566 (21.7)	60
N1	466 (17.9)	45
N2	624 (24)	33
N3	948 (36.4)	18
Surgical approach			< 0.001
Proximal gastrectomy	234 (9)	38
Distal gastrectomy	1586 (60.9)	39
Total gastrectomy	784 (30.1)	22
Radical surgery			< 0.001
R0	2125 (81.7)	39
R1/R2	479 (18.3)	13
Combined resection			< 0.001
Presence	89 (3.4)	18
Absence	2125 (96.6)	34

Table 3 Univariate and multivariate analyses of postoperative prognostic factors for advanced gastric cancer

	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Gender	1.027 (0.925-1.139)	0.619	-	-
Age	0.983 (0.898-1.076)	0.705	-	-
Lymphatic and/or blood vessel invasion	0.733 (0.653-0.823)	< 0.001	0.869 (0.770-0.981)	< 0.001
Borrmann type	1.591 (1.481-1.710)	< 0.001	1.217 (1.130-1.312)	0.023
Tumor location	1.120 (1.061-1.183)	< 0.001	0.990 (0.940-1.043)	0.718
Tumor size (mm)	1.842 (1.667-2.036)	< 0.001	1.149 (1.031-1.280)	0.012
Histologic grade	1.248 (1.135-1.372)	< 0.001	1.021 (0.927-1.125)	0.667
pT category	1.413 (1.334-1.497)	< 0.001	1.180 (1.180-1.258)	< 0.001
pN category	1.622 (1.553-1.694)	< 0.001	1.447 (1.382-1.515)	< 0.001
Surgical approach	1.474 (1.360-1.598)	< 0.001	1.076 (0.988-1.172)	0.094
Radical surgery	2.906 (2.607-3.239)	< 0.001	2.029 (1.810-2.276)	< 0.001
Combined resection	0.641 (0.508-0.809)	< 0.001	0.859 (0.677-1.090)	0.212