Clinical characteristics and surgical treatment of schwannomas of the esophagus and stomach: A case series and systematic review

Table 1 Clinical characteristics of esophageal and gastric schwannomas, n (%)

Characteristics	Institutional experience (n = 6)	Literature review1 (n = 317)
Location
Stomach	5 (83.3)	301 (94.9)
Esophagus	1 (16.6)	16 (5)
Size
1-2 cm	Stomach: 2 (33)	Stomach: 20
2.1 – 4 cm	Stomach: 1 (16.6)	Stomach: 66; Esophagus: 1
> 4.1 cm	Stomach: 2 (33); Esophagus: 1 (16.6)	Stomach: 88; Esophagus: 3
Follow-up with disease- free survival in months
< 12	Stomach: 1 (16.6); Esophagus: 1 (16.6)	Stomach: 18
43823	0	Stomach: 21; Esophagus: 2
25 – 36	0	Stomach: 8
>36	Stomach: 4 (66.6)	Stomach: 78; Esophagus: 2
Age
< 30 yr	Stomach: 1 (16.6)	Stomach: 6 (2.47); Esophagus: 3 (18.75)
30-40 yr	Stomach: 1 (16.6)	Stomach: 18 (7.43); Esophagus: 1 (6.25)
41-50 yr	Esophagus: 1 (16.6)	Stomach: 49 (20.24); Esophagus: 3 (18.75)
51-60 yr	Stomach: 2 (33.3)	Stomach: 72 (29.75); Esophagus: 4 (25)
>60 yr	Stomach: 1 (16.6)	Stomach: 97 (40.08); Esophagus 5 (31.25)

¹Only the cases in which the data is reported explicitly are shown.

Table 2 Clinical and pathological characteristics

Case	Sex	Age, yr	Tumor	Size	Location	Margins	IHQ
1	F	41	Schwannoma	7.5 cm x4.5 cm x1.9 cm	Esophagus	Positive	S100+, GFAP-, CD117-, COD1-, KI67 <1%
2	F	37	Schwannoma	4.2 cm x3.1 cm	Stomach	Negative	S100+, CD117-, DOG1-, CD34-, Actina-, Desmina-, CD56-.
3	F	29	Schwannoma	2.3 cm x2.3 cm	Stomach	Negative	S100+, CD56+, DOG1-, CD117 ,CD34-, Desmina-, Actina-.
4	F	67	Schwannoma	1.9 cm x1.5 cm	Stomach	Negative	DOG1-, CD117-, CD34-, Actina-, Calponina-, S-100+, CD56-.
5	F	54	Schwannoma	4.5 cm x4.3 cm x4 cm	Stomach	Negative	S100+, CD34+, CD117-, Actina-.
6	F	55	Schwannoma	8 cm x5 cm	Stomach	Negative	DOG1-, CD117-, S100+, KI671%.