Systematic Reviews
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2019; 11(9): 750-760
Published online Sep 15, 2019. doi: 10.4251/wjgo.v11.i9.750
Clinical characteristics and surgical treatment of schwannomas of the esophagus and stomach: A case series and systematic review
Jesús Morales-Maza, Francisco Ulises Pastor-Sifuentes, Germán E Sánchez-Morales, Emilio Sanchez-Garcia Ramos, Oscar Santes, Uriel Clemente-Gutiérrez, Adriana Simoneta Pimienta-Ibarra, Heriberto Medina-Franco
Jesús Morales-Maza, Francisco Ulises Pastor-Sifuentes, Germán E Sánchez-Morales, Emilio Sanchez-Garcia Ramos, Oscar Santes, Uriel Clemente-Gutiérrez, Adriana Simoneta Pimienta-Ibarra, Heriberto Medina-Franco, Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City14080, Mexico
Author contributions: Morales-Maza J, Pastor-Sifuentes FU, Sánchez-Morales GE and Medina-Franco H contributed equally to this study; Santes O and Clemente-Gutiérrez U performed the research and analyzed the data; Pimienta-Ibarra AS and Sanchez-Garcia Ramos E. wrote the paper.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Heriberto Medina-Franco, FACS, MD, Associate Professor, Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,Vasco de Quiroga 15, Sección XVI, Tlalpan, Mexico City14080, Mexico.herimd@hotmail.com
Telephone: +1-52-54870900 Fax: +1-52-54870900
Received: February 12, 2019
Peer-review started: February 15, 2019
First decision: April 15, 2019
Revised: May 5, 2019
Accepted: August 18, 2019
Article in press: August 19, 2019
Published online: September 15, 2019
Processing time: 213 Days and 8.8 Hours
Abstract
BACKGROUND

Gastrointestinal schwannomas are slow-growing benign mesenchymal neoplasms that originate from Schwann cells of the nerve sheath of Auerbach´s plexus or less frequently from Meissner´s plexus. The main differential diagnosis of gastric schwannomas are the gastrointestinal stromal tumors (GISTs), which are classified by their immunohistochemistry. The treatment of choice for gastric schwannomas is surgery where laparoscopy plays an important role. Wedge resection, subtotal or total gastrectomy can be done. In its counterpart, esophageal schwannomas are benign tumors of the esophagus that are very uncommon since they comprise less than 2% of all esophageal tumors. The main differential diagnosis is the leiomyoma which corresponds to the most common benign esophageal tumor, followed by GIST. The treatment consists on tumoral enucleation or esophagectomy.

AIM

To review the available literature about gastrointestinal schwannomas; especially lesions from de stomach and esophagus, including diagnosis, treatment, and follow up, as well as, reporting our institutional experience.

METHODS

A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guidelines. The following databases were used for reviewing process: PubMed, Ovid, MEDLINE, and Scopus. Only English language manuscripts were included. All gastrointestinal schwannomas specifically located in the esophagus and stomach were included. Cases that did not report long-term follow-up were excluded.

RESULTS

Gastric localization showed a higher prevalence in both, the literature review and our institution: 94.95% (n = 317) and 83% (n = 5) respectively. With a follow-up with disease-free survival greater than 36 mo in most cases: 62.01% (n = 80) vs 66.66% (n = 4). In both groups, the median size was > 4.1 cm. Surgical treatment is curative in most cases

CONCLUSION

Schwannoma must be taken into account in the differential diagnosis of gastrointestinal mesenchymal tumors. It has a good prognosis, and most are benign. A disease-free survival of more than 36 mo can be achieved by surgery.

Keywords: Schwannoma; Esophagus; Stomach; Surgery; Systematic review

Core tips: We performed a systematic review of the literature searching two types of rare tumors; esophageal and gastric schwannomas. We review its form of presentation, diagnosis, differential diagnosis and treatment. We also performed a systematic review trying to gather all case reports and case series in a single paper. We have found 16 cases of esophageal schwannomas and 301 cases of gastric schwannomas in all literature. We also reviewed our institutional experience with the report of 6 cases of gastrointestinal schwannomas, 1 is esophageal and 5 are gastric.