Impact of regular enteral feeding via jejunostomy during neo-adjuvant chemotherapy on body composition in patients with oesophageal cancer

Table 1 Patient demographics

	No. of patients, n = 15
Age in yr, mean ± SD	61.3 ± 12.8
Sex
M	11 (73.3)
F	4 (26.7)
Tumour site
Mid oesophagus	1 (6.6)
Lower oesophagus	4 (26.7)
Oesophageal-gastric junction	10 (66.7)
Histology
Adenocarcinoma	11 (73.3)
Squamous cell cancer	3 (20.0)
Other	1 (6.7)
Stage
I	1 (6.6)
II	4 (26.7)
III	10 (66.7)
Neo-adjuvant chemotherapy protocol
ECX	7 (46.7)
ECF	3 (20)
EOX	1 (6.6)
CX	2 (13.3)
CF	2 (13.3)

Values are number of patients with percentages in parentheses unless indicated otherwise. SD: Standard deviation; M: Male; F: Female; ECX: Epirubicin/cisplatin/capecitabine; ECF: Epirubicin/cisplatin/5-fluorouracil; EOX: Epirubicin/oxaliplatin/capecitabine; CX: Cisplatin/capecitabine; CF: Cisplatin/5-fluorouracil.

Table 2 Change in body composition from diagnosis to post neo-adjuvant chemotherapy following regular enteral feeding via jejunostomy, n = 15

	Diagnosis	Post-chemotherapy	P value
Weight, mean ± SD, kg	74.5 ± 14.1	74.8 ± 13.1	0.6591
BMI, mean ± SD, kg/m2)	26.0 ± 3.8	26.1 ± 3.4	0.6231
Lumbar skeletal muscle index as cm2/m2, mean ± SD	45.8 ± 8.0	43.5 ± 7.3	0.0481
Lumbar adipose tissue index as cm2/m2, mean ± SD,	124.0 ± 53.7	124.6 ± 47.9	0.8781
Sarcopenic	5 (33.3)	9 (60.0)	0.2192
Myosteatotic	8 (53.3)	8 (53.3)	1.0002

¹Paired t-test;

²McNemar’s test. Values are number of patients with percentages in round parentheses unless indicated otherwise. SD: Standard deviation; BMI: Body mass index.

Table 3 Individual values for changes in lumbar skeletal muscle index (cm²/m²) from diagnosis to post neo-adjuvant chemotherapy following regular enteral feeding via jejunostomy

Patient ID	Diagnosis	After neo-adjuvant chemotherapy
Patient 1	45.86	43.20
Patient 2	46.27	42.87
Patient 3	44.44	40.65
Patient 4	24.25	27.50
Patient 5	47.97	43.77
Patient 6	54.85	53.80
Patient 7	41.05	35.91
Patient 8	43.79	53.48
Patient 9	47.00	45.39
Patient 10	54.47	50.53
Patient 11	40.50	39.20
Patient 12	39.15	36.71
Patient 13	52.26	44.59
Patient 14	56.74	53.76
Patient 15	48.84	42.05

Table 4 Individual values for changes in lumbar adipose tissue index (cm²/m²) from diagnosis to after neo-adjuvant chemotherapy following regular enteral feeding via jejunostomy

Patient ID	Diagnosis	After neo-adjuvant chemotherapy
Patient 1	166.10	160.91
Patient 2	82.71	131.25
Patient 3	102.27	112.29
Patient 4	187.18	177.17
Patient 5	62.08	64.25
Patient 6	192.85	202.49
Patient 7	80.79	88.04
Patient 8	102.87	93.52
Patient 9	10.03	26.22
Patient 10	159.49	146.65
Patient 11	157.76	148.82
Patient 12	197.29	186.82
Patient 13	101.62	93.82
Patient 14	118.47	110.45
Patient 15	137.98	126.63