Plasma extracellular cold inducible RNA-binding protein levels are elevated for 1 month post-colectomy which may promote metastases

Figure 1 Enzyme-linked immunosorbent assay determined preoperative and postoperative plasma levels of cold-inducible RNA-binding protein in patients with colorectal cancer. Extracellular cold-inducible RNA-binding protein (CIRP) levels are reported as mean ± SD. Preoperative (Preop) vs post-operative day (POD) 1 (n = 83, ^aP < 0.001); Preop vs POD 3 (n = 77, ^aP < 0.001); Preop vs POD 7-13 (n = 57, ^aP < 0.001); Preop vs POD 14 -20 (n = 30, ^aP < 0.001); Preop vs POD 21-27(n = 21, ^aP < 0.001); POD 28-41 time point (n = 19, ^bP = not significant). Statistical significance is expressed as ^aP < 0.001. POD: Post-operative day; Preop: Preoperative; eCIRP: Extracellular cold-inducible RNA-binding protein.