Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2025; 17(4): 100678
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.100678
Plasma extracellular cold inducible RNA-binding protein levels are elevated for 1 month post-colectomy which may promote metastases
H M C Shantha Kumara, Poppy Addison, Xiao-Hong Yan, Anuj Raj Sharma, Neil Mitra, Hansani N Angammana, Yanni Hedjar, Yi-Ru Chen, Vesna Cekic, Whelan L Richard
H M C Shantha Kumara, Anuj Raj Sharma, Neil Mitra, Hansani N Angammana, Yi-Ru Chen, Vesna Cekic, Whelan L Richard, Division of Colon and Rectal Surgery, Department of Surgery, Lenox Hill Hospital, Northwell Health, New York, NY 10028, United States
H M C Shantha Kumara, Anuj Raj Sharma, Neil Mitra, Hansani N Angammana, Yi-Ru Chen, Vesna Cekic, Whelan L Richard, Northwell, New Hyde Park, New York, NY 10042, United States
Poppy Addison, Division of Colon and Rectal Surgery, Department of Surgery, Staten Island University Hospital, Northwell Health, Staten Island, NY 10305, United States
Xiao-Hong Yan, Department of Pathology and Cell Biology, Columbia University Medical Center, Vanderbilt Clinic, New York, NY 10032, United States
Yanni Hedjar, Department of Surgery, Brookdale Hospital and Medical Center, Brooklyn, NY 11212, United States
Whelan L Richard, Donald and Barbara Zucker School of Medicine, Hofstra/Northwell 500 Hofstra Blvd, Hempstead, NY 11549, United States
Author contributions: Shantha Kumara HMC played a pivotal role in conceptualizing the study, its design, processing of samples, data interpretation; Yan XH, and Addison P were instrumental in the aggregation of clinical data from human subjects; Sharma AR, Mitra N, Angammana HN, Hedjar Y, Chen YR and Cekic V contributed to the collection, processing, and data analysis of human samples; Both Shantha Kumara HMC and Yan XH were responsible for the statistical analysis and interpretation of the results. Richard WL contributed significantly to the conception of the study, its structural design, data interpretation, and critical manuscript revisions. All authors actively participated in drafting the article, made critical amendments, and endorsed the final version submitted for publication.
Supported by The Thompson Family Foundation.
Institutional review board statement: The current study utilized materials collected from patients who provided preoperative consent to partake in an Institutional Review Board approved tissue and data banking protocol, overseen by the Colorectal Service at Mount Sinai West. The protocol was sanctioned by the Institutional Review Board of the Mount Sinai School of Medicine in New York, NY (IRB Reference No: GCO#1: 16-2619).
Conflict-of-interest statement: None of the authors associated with this manuscript have any conflicts of interest or financial affiliations to declare.
Data sharing statement: The datasets generated and/or analyzed during the current study are not publicly available other than the included in the article due to protection of patient privacy and biosecurity reasons; all data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Whelan L Richard, FACS, MD, Professor, Division of Colon and Rectal Surgery, Department of Surgery, Lenox Hill Hospital, Northwell Health, 1421 Third Avenue-Suite PH, New York, NY 10028, United States. rwhelan1@northwell.edu
Received: August 22, 2024
Revised: January 10, 2025
Accepted: February 19, 2025
Published online: April 15, 2025
Processing time: 214 Days and 21.9 Hours
Core Tip

Core Tip: Our findings have substantiated that plasma collected during the second and third weeks post minimally invasive colorectal cancer resection (MICR) possesses the capacity to stimulate endothelial cell proliferation, invasion, and migration, which are essential prerequisites for neovascularization. This study, investigating perioperative plasma extracellular cold-inducible RNA-binding protein (eCIRP) levels in the context of MICR, evaluated six postoperative time points and unveiled that blood levels remain significantly elevated above preoperative baseline for a month after surgery. eCIRP and acts as a damage-associated molecular pattern molecule that promotes an inflammatory response (including TNF-α, IL-6 and HMGB production in macrophages, neutrophils, lymphocytes and dendritic cells. Elevated levels of eCIRP together with other elevated angiogenic proteins including T cell immunoglobulin and mucin domain-3 and monocyte chemo-attractant protein-1 may enhance macrophage activity and promote immune tolerance, potentially facilitating tumor growth and progression.