Research progress on the effect of pyroptosis on the occurrence, development, invasion and metastasis of colorectal cancer

Figure 1 Summary of the timeline of research and reports on pyroptosis. ICE: Caspase-1; IL: Interleukin; GSDMD: Gasdermin D; TNF: Tumor Necrosis Factor. Citation: The authors have obtained the permission for figure using from the BioRender.com (Supplementary material)[203].

Figure 2 The role and summary of pyroptosis related signaling pathway in tumor. GSDM: Gasdermines; TNF: Tumor necrosis factor. Citation: The authors have obtained the permission for figure using from the BioRender.com (Supplementary material)[203].

Figure 3 Summary of pyroptosis related pathways. GSDM: Gasdermines.

Figure 4 Pyroptosis is a process by which specific receptors on the surface of colorectal cancer. GSSG: Oxidized glutathione; MLKL: Mixed lineage kinase domain-like; DAMP: Damage-associated molecular patterns; GPX: Glutathione peroxidase; TNF: Tumor necrosis factor. Citation: The authors have obtained the permission for figure using from the BioRender.com (Supplementary material)[203].

Figure 5 Pyroptosis induces immune cells in the colorectal cancer microenvironment. MDSC: Myeloid-derived suppressor cells. Citation: The authors have obtained the permission for figure using from the BioRender.com (Supplementary material)[203].

Figure 6 Pyroptosis and the colorectal cancer tumor microenvironment. A: Granzyme-mediated pathway; B: Non-canonical pathway; C: Canonical pathway. NLRP: Nucleotide-binding oligomerization domain (NOD)-like receptor family, pyrin domain-containing protein; DAMP: Damage-associated molecular pattern; TNF: Tumor necrosis factor; TRADD: Tumor necrosis factor receptor type 1-associated death domain protein; ASC: Apoptosis-associated speck-like protein containing a CARD; PAMP: Pathogen-associated molecular pattern; IL: Interleukin. Citation: The authors have obtained the permission for figure using from the BioRender.com (Supplementary material)[203].