Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3410-3427
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3410
Research progress on the effect of pyroptosis on the occurrence, development, invasion and metastasis of colorectal cancer
Xu Wang, Qi-Hang Yin, Lin-Lu Wan, Ruo-Lan Sun, Gang Wang, Jun-Fei Gu, De-Cai Tang
Xu Wang, Qi-Hang Yin, Lin-Lu Wan, Ruo-Lan Sun, Jun-Fei Gu, De-Cai Tang, School of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Gang Wang, Department of Ana and Intestine Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Co-corresponding authors: Jun-Fei Gu and De-Cai Tang.
Author contributions: Wang X wrote the manuscript; Yin QH, Wan LL, Sun RL, and Wang G collected the data; Gu JF and Tang DC guided the study; and all authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work. Gu JF and Tang DC contributed equally to this work as co-corresponding authors. The reasons for designating Gu JF and Tang DC as co-corresponding authors are the supervisors and principals of this study.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: De-Cai Tang, PhD, Full Professor, School of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. talknow@njucm.edu.cn
Received: April 24, 2024
Revised: May 28, 2024
Accepted: July 4, 2024
Published online: August 15, 2024
Processing time: 105 Days and 12.3 Hours
Core Tip

Core Tip: Pyroptosis plays an important role in inflammatory diseases and malignant tumors. With the further study of pyroptosis, an increasing number of studies have shown that the pyroptosis pathway can regulate the tumor microenvironment and antitumor immunity of colorectal cancer and is closely related to the occurrence, development, treatment and prognosis of colorectal cancer. This review aimed to explore the molecular mechanism of pyroptosis and the role of pyroptosis in the occurrence, development, treatment and prognosis of colorectal cancer (CRC) and to provide ideas for the clinical diagnosis and treatment of CRC.