Network pharmacology- and molecular docking-based exploration of the molecular mechanism underlying Jianpi Yiwei Recipe treatment of gastric cancer

Figure 1 Venn diagram of drug targets and disease targets. In total, 180 overlapping genes were identified between gastric cancer-related genes and drug-related genes.

Figure 2 Active ingredient-core target interaction network. Green, orange, and blue indicate drug, active ingredient, and targeted gene, respectively.

Figure 3 Protein-protein interaction network of intersecting genes.

Figure 4 Screening of key genes by topology analysis of the protein-protein interaction network. Pink indicates targeted gene, yellow indicates key genes identified using the NetworkAnalyzer plug-in.

Figure 5 Kyoto Encyclopedia of Genes and Genomes and gene ontology enrichment of key genes. A: Gene ontology enrichment analysis, including biological process, cellular component, and molecular function; B: Top 20 Kyoto Encyclopedia of Genes and Genomes pathway enrichment.

Figure 6 Molecular docking of quercetin with various targets. A: Action mode of quercetin with target AKT1 (PDB ID: 1UNQ); B: Action mode of quercetin with target TP53 (PDB ID: 1A1U); C: Action mode of quercetin with target tumor necrosis factor (PDB ID: 7ATB). TNF: Tumor necrosis factor.