Network pharmacology- and molecular docking-based exploration of the molecular mechanism underlying Jianpi Yiwei Recipe treatment of gastric cancer

doi:10.4251/wjgo.v16.i7.2988

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Jul 15, 2024 (publication date) through Jan 3, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Gastrointest Oncol. Jul 15, 2024; 16(7): 2988-2998
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.2988

Network pharmacology- and molecular docking-based exploration of the molecular mechanism underlying Jianpi Yiwei Recipe treatment of gastric cancer

Peng Chen, Huan-Yu Wu

Peng Chen, Huan-Yu Wu, Traditional Chinese Medicine, The First Teaching Hospital of Tianjin University, Tianjin 300193, China

Author contributions: Chen P designed the research and wrote the first manuscript; Chen P and Wu HY contributed to conceiving the research and analyzing data; Chen P conducted the analysis and provided guidance for the research; and all authors reviewed and approved the final manuscript.

Conflict-of-interest statement: There is no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Peng Chen, BMed, Doctor, Traditional Chinese Medicine, The First Teaching Hospital of Tianjin University, No. 88 Changling Road, Xiqing District, Tianjin 300193, China. ajisan4@163.com

Received: February 26, 2024
Revised: April 26, 2024
Accepted: May 14, 2024
Published online: July 15, 2024
Processing time: 137 Days and 14.8 Hours

Core Tip

Core Tip: Traditional Chinese medicine plays an important complementary and alternative medical system, natural anticancer compounds were shown to have good efficacy, few side effects, and low toxicity, making them effective in anti-tumor therapy. This study revealed that Jianpi Yiwei Recipe plays a therapeutic role in gastric cancer through multiple components, targets, and pathways through network pharmacology and molecular docking.