Human β-defensin-1 activates autophagy in human colon cancer cells via regulation of long non-coding RNA TCONS_00014506

Figure 1 Human β-defensin-1-induced inhibition of the mammalian target of rapamycin in human colon cancer and autophagy activation via long non-coding RNA TCONS_0014506. Human β-defensin-1 (hBD1)-treated cancer cells exhibit proliferation suppression, autophagy activation, and upregulation of long non-coding RNA TCONS_00014506. Genetic Inhibition of this RNA reverses the enhanced autophagic response by hBD1. However, the role of autophagy activation in cancer cells by treatment needs further studies. hBD1: Human β-defensin-1; mTOR: Mammalian target of rapamycin; LncRNA: Long non-coding RNA.