Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 2894-2901
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.2894
Human β-defensin-1 activates autophagy in human colon cancer cells via regulation of long non-coding RNA TCONS_00014506
Nabil Eid, Fabian Davamani
Nabil Eid, Anatomy Department, Division of Human Biology, School of Medicine, International Medical University, Kuala Lumpur 57000, Malaysia
Fabian Davamani, Division of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, International Medical University, Kuala Lumpur 57000, Malaysia
Author contributions: Eid N and Davamani F wrote and revised the manuscript; and all authors read and approved the final draft.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nabil Eid, Doctor, MD, PhD, Academic Editor, Associate Professor, Senior Lecturer, Senior Scientist, Anatomy Department, Division of Human Biology, School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Received: March 7, 2024
Revised: April 26, 2024
Accepted: May 14, 2024
Published online: July 15, 2024
Processing time: 127 Days and 0.1 Hours
Core Tip

Core Tip: Autophagy is an essential mechanism for clearing harmful cellular components, specifically upon exposure to various stressors such as chemotherapy. The activation of autophagy in colon cancer cells under human β-defensin-1 treatment is mediated by mammalian target of rapamycin suppression and upregulation of long noncoding RNAs (lncRNA) TCONS_00014506. Targeting this lncRNA could have prognostic, diagnostic, and therapeutic implications in colon cancer.