Review
Copyright ©The Author(s) 2024.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2335-2349
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2335
Figure 1
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Figure 1 Iron metabolism and ferroptosis. Created with BioRender.com. TF: Tissue Factor; LTF: Lactoferrin; TFRC: Transferrin receptor; HB: Hemoglobin; HP: Haptoglobin; HPX: Hemopexin; LRP: Lipoprotein receptor protein; HAMP: Human hepcidin; CP: Ceruloplasmin; CAT: Catalase; ETC: Extracellular tissue; PCBP: Poly(rC)-Binding Protein; POR: P450 Oxidoreductase; NOXs: NADPH Oxidases; XDH: Xanthine dehydrogenase; ALOXs: Arachidonate lipoxygenases; LIP: Lymphocyte inhibitor peptide.
Figure 2
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Figure 2 Anti-liver cancer therapy by targeting ferroptosis. Created with BioRender.com. FAT: Fatty acid translocase; FATP: Fatty acid transport protein; AA: Amino acid; RAS: Rats arcomaviral oncogene; NAPDH: Nicotinamide adenine dinucleotide phosphate hydrogen; ROS: Reactive oxygen species; RAF: Rapidly accelerated fibrosarcoma; GSH: Glutathione.
Figure 3
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Figure 3 The mechanisms of cell death including apoptosis, necrosis, autophagy and ferroptosisin in hepatocellular carcinoma. Created with BioRender.com. GED: Gas electron detector; BCL: B-Cell lymphoma; APAF: Apoptotic protease-activating factor; CNX: Calnexin; CLP: Caudal-like protein; CAPN: Calpain; TRA: Tumor-related antigen; ASP: Asparaginase; HLH: Hemophagocytic lymphohistiocytosis; TFEB: Transcription factor EB; GSH: Glutathione; SOD: Superoxide dismutase; FTN: Ferritin; HSF: Heat shock factor; ROS: Reactive oxygen species.
Figure 4
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Figure 4 Preparation process of iron-dead biomaterials. Created with BioRender.com. NHS: N-Hydroxysuccinimide; EDC: Ethyl-dimethylaminopropyl carbodiimide; SOD: Superoxide dismutase; GSSG: Glutathione disulfide; GSH: Glutathione; HSA: Human serum albumin.
Figure 5
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Figure 5 Both lipid catabolism and anabolic changes affect lipid peroxidation during ferroptosis. Created with BioRender.com. FASN: Fatty acid synthase; FABP: Fatty acid-binding protein; PUFA: Polyunsaturated fatty acids; LIPE: Lipase E; MGLL: Monoglyceride lipase; ACAC: Acetyl-CoA carboxylase.