Prognostic analysis of related factors of adverse reactions to immunotherapy in advanced gastric cancer and establishment of a nomogram model

Figure 1 Occurrence onset of different immune-related adverse reactions.

Figure 2 Receiver operating characteristic curve for predicting immune-related adverse reactions with two combined indices. Treg: Regulatory T cells; AUC: Area under the curve; CI: Confidence interval.

Figure 3 Kaplan-Meier analysis of progression-free survival and overall survival of patients in the two groups. A: Progression-free survival; B: Overall survival. PFS: Progression-free survival; OS: Overall survival; irAEs: Immune-related adverse reactions.

Figure 4 Nomogram predicting postoperative complications (≥ grade II) after radical resection of gastric cancer.

Figure 5 Receiver operating characteristic curve and calibration curve for predicting postoperative complications after radical resection of gastric cancer in the training set and validation set. A: Receiver operating characteristic (ROC) curve of nomogram in the training set [nomogram, area under the curve (AUC) = 0.625; male, AUC = 0.550; age ≥ 60 years, AUC = 0.572; maximum diameter of tumor ≥ 5 cm, AUC = 0.560; total gastrectomy, AUC = 0.553); B: ROC curve of nomogram in the validation set (nomogram, AUC = 0.646; male, AUC = 0.552; age ≥ 60 years, AUC = 0.528; maximum diameter of tumor ≥ 5 cm, AUC = 0.566; total gastrectomy, AUC = 0.564); C: Calibration curve in the training set; D: Calibration curve in the validation set.