Effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions

Figure 1 Staining results of mouse gastric sinus tissue. A: HE staining of mouse gastric antrum tissue (400 ×); B: Gimesa-stained image of mouse gastric sinus tissue (200 ×). The arrows indicate the location of the Helicobacter pylori.

Figure 2 Pathological observation of HE stain of mouse stomach tissue (400 ×). A: Control group; B: N-methyl-N-nitrosourea (MNU) group; C: Helicobacter pylori + MNU group; D: Moluodan group.

Figure 3 Relative expression of Wnt1, β-catenin, cyclinD1, epidermal growth factor, c-Myc m-RNA in each group. EGF: Epidermal growth factor; MNU: N-methyl-N-nitrosourea; H. pylori: Helicobacter pylori.

Figure 4 Western blot of Wnt1, β-catenin, cyclinD1, epidermal growth factor, and c-Myc protein expression in each group. A: Control group; B: Helicobacter pylori +N-methyl-N-nitrosourea (MNU) group; C: MNU group; D: Moluodan group.