Copyright
©The Author(s) 2023.
World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1105-1118
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1105
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1105
Figure 1 The process of ferroptosis, mainly including glutathione metabolism, iron metabolism and lipid peroxidation reaction.
Figure 2 The crosstalk between ferroptosis and immunotherapy.
The IFNγ released by CD8+ T cells activates ferroptosis in tumor cells through the JAK/STAT1 pathway. Ferroptotic tumor cells then release DAMPs which contributes to immune activation. IFN: Interferon; DAMPs: Damage-associated molecular patterns.
- Citation: Fan X, Fan YT, Zeng H, Dong XQ, Lu M, Zhang ZY. Role of ferroptosis in esophageal cancer and corresponding immunotherapy. World J Gastrointest Oncol 2023; 15(7): 1105-1118
- URL: https://www.wjgnet.com/1948-5204/full/v15/i7/1105.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i7.1105