Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1105-1118
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1105
Role of ferroptosis in esophageal cancer and corresponding immunotherapy
Xin Fan, Yan-Ting Fan, Hui Zeng, Xi-Qi Dong, Min Lu, Zhi-Yuan Zhang
Xin Fan, Zhi-Yuan Zhang, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China
Yan-Ting Fan, Xi-Qi Dong, The First Clinical Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China
Hui Zeng, Department of Stomatology, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China
Min Lu, Department of Emergency Medicine, Shangrao Hospital Affiliated to Nanchang University, Shangrao 334000, Jiangxi Province, China
Author contributions: Fan X and Fan YT drafted the manuscript; Zeng H, Dong XQ, Lu M and Zhang ZY contributed to the editing of the manuscript; all authors contributed to the article and approved the submitted version.
Supported by the Central Funds Guiding the Local Science and Technology Development of China, No. 20221ZDG020066.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Yuan Zhang, PhD, Doctor, Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330000, Jiangxi Province, China. zzyent@126.com
Received: December 28, 2022
Peer-review started: December 28, 2022
First decision: January 12, 2023
Revised: February 28, 2023
Accepted: April 24, 2023
Article in press: April 24, 2023
Published online: July 15, 2023
Processing time: 195 Days and 18.3 Hours
Core Tip

Core Tip: Recent studies suggested that ferroptosis plays an important role in the development, progression and metastasis of esophageal cancer (EC). Meanwhile, ferroptosis influences the outcome of immunotherapy to some extent. This review aims to elucidate the mechanism of ferroptosis and the ferroptosis research progress in the treatment of EC. We further elaborate the interaction between ferroptosis and immunotherapy, and the related mechanisms of ferroptosis participation in the immunotherapy of EC, so as to provide new directions and ideas for the treatment of EC.