Role of sirtuins in esophageal cancer: Current status and future prospects

Figure 1 Schematic representation of the subcellular localization of sirtuins. Catalyst domains reflecting sirtuin classes are shown in purple (Class I), green (Class II), blue (Class III) and red (Class IV). SIRT: Sirtuin.

Figure 2 Roles of sirtuins in cell proliferation, apoptosis, invasion and migration. E2F1: E2F transcription factor 1; E-cadherin: Cadherin 1; ERK1/2: Extracellular signal-regulated kinases 1/2; FOXO: Forkhead class O transcription factor; NF-κB: Nuclear factor kappa B; NRF2: Nuclear factor erythroid 2-related factor 2; IRT: Sirtuin; SMAD4: SMAD family member 4.