Comprehensive analysis of the potential role and prognostic value of sine oculis homeobox homolog family in colorectal cancer

Figure 1 Sine oculis homeobox homologs in different cancerous tissues and corresponding normal tissues in the Tumor Immune Estimation Resource 2. 0 database. A: Sine oculis homeobox homolog (SIX)1; B: SIX2; C: SIX3; D: SIX4; E: SIX5; F: SIX6. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. SIX: Sine oculis homeobox homolog; TPM: Transcript count per million.

Figure 2 Expression of sine oculis homeobox homolog family members in The Cancer Genome Atlas colon and rectal cancer tissues in the UCSC Xena database. Red: Normal tissue; Blue: Cancerous tissue. One-way analysis of variance was utilized for statistical significance. ^cP < 0.001. SIX: Sine oculis homeobox homolog; TCGA: The Cancer Genome Atlas.

Figure 3 Overall survival of colorectal cancer patients estimated by individual expression of sine oculis homeobox homolog family members. A: Sine oculis homeobox homolog (SIX)1; B: SIX2; C: SIX3; D: SIX4; E: SIX5; F: SIX6. HR: Hazard ratio; SIX: Sine oculis homeobox homolog.

Figure 4 Disease-free survival of colorectal cancer patients estimated by individual expression of sine oculis homeobox homolog family members. A: Sine oculis homeobox homolog (SIX)1; B: SIX2; C: SIX3; D: SIX4; E: SIX5. SIX: Sine oculis homeobox homolog.

Figure 5 Sine oculis homeobox homolog 4-associated genes. A: All associated genes; B: Top 50 positively-correlated genes; C: Top 50 negatively-correlated genes. SIX4: Sine oculis homeobox homolog 4.

Figure 6 Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses of sine oculis homeobox homolog 4-associated genes. A: Kyoto Encyclopedia of Genes and Genomes; B: Biological process; C: Cellular component; D: Molecular function.

Figure 7 Relationship between sine oculis homeobox homolog 4 level and clinicopathological parameters of colorectal cancer patients. A: Tumor size; B: Lymph node status; C: Metastasis; D: Stage. SIX: Sine oculis homeobox homolog.

Figure 8 Representative sine oculis homeobox homolog 4 staining in colorectal cancer and adjacent normal tissues from a patient. A: Colorectal cancer tissue; B: Adjacent normal tissue.

Figure 9 Kaplan-Meier analysis of sine oculis homeobox homolog 4 expression on overall survival of colorectal cancer patients. SIX: Sine oculis homeobox homolog.