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©The Author(s) 2022.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 38-54
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.38
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.38
Figure 1 Schematic of receptor tyrosine kinases/KRAS and transforming growth factor beta/SMAD signaling pathways and downstream key transcription factors regulating the proteosome including FOXO, NF-Y, NFE2L2, and heat shock factors 1/2.
Stabilized mutant p53 is involved in proteostasis transcription factors deregulation. For details see text. RTK: Receptor tyrosine kinases; TGFβ: Transforming growth factor beta; hHSF1/2: Heat shock factors 1/2; mtp53: Mutant p53.
- Citation: Murugan NJ, Voutsadakis IA. Proteasome regulators in pancreatic cancer. World J Gastrointest Oncol 2022; 14(1): 38-54
- URL: https://www.wjgnet.com/1948-5204/full/v14/i1/38.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v14.i1.38