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World J Gastrointest Oncol. Jan 15, 2022; 14(1): 38-54
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.38
Proteasome regulators in pancreatic cancer
Nirosha J Murugan, Ioannis A Voutsadakis
Nirosha J Murugan, Department of Biology, Algoma University, Sault Sainte Marie P6A3T6, ON, Canada
Ioannis A Voutsadakis, Department of Medical Oncology, Sault Area Hospital, Sault Sainte Marie P6A3T6, ON, Canada
Author contributions: Voutsadakis IA conceived and designed the study, both authors reviewed the literature, wrote, revised and approved the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest regarding this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Ioannis A Voutsadakis, MD, PhD, Associate Professor, Doctor, Department of Medical Oncology, Sault Area Hospital, 750 Great Northern Road, Sault Sainte Marie P6A3T6, ON, Canada.
Received: February 23, 2021
Peer-review started: February 23, 2021
First decision: March 29, 2021
Revised: April 14, 2021
Accepted: December 2, 2021
Article in press: December 2, 2021
Published online: January 15, 2022
Core Tip

Core Tip: Pancreatic adenocarcinoma is a gastrointestinal cancer with high incidence and bleak outcomes. The molecular pathways involved in the pathogenesis of the disease have been increasingly clarified in recent years. This article reviews the role of proteostasis regulation through the proteasome in pancreatic cancer. Major molecular pathways affected in pancreatic cancer closely interconnect with regulators of the proteasome.