Minimally invasive surgical treatment of intrahepatic cholangiocarcinoma: A systematic review

Figure 1 PRISMA flow-chart. Figure reported the diagram of our systematic review of the literature, performed in 4 databases from Jan 1, 2009 up to Jan 1, 2021. Search terms included: "cholangiocarcinoma", "intrahepatic", "laparoscopic", "surgery", "minimally invasive", "robotic surgery" "biliary neoplasm", "liver resection" and "hepatectomy". Inclusion criteria are in the big circle-box. Major reasons for exclusion were the absence of patients treated both with laparoscopic and open approach (n = 114) and the inclusion of other tumor types besides intrahepatic cholangiocarcinoma (n = 36). Further reasons for exclusion were population treated with palliative intent or case series or absence of specific data on the post-operative outcomes. This led to the final selection of 9 studies which fulfilled the inclusion criteria. ICC: Intrahepatic cholangiocarcinoma.