Patrone R, Izzo F, Palaia R, Granata V, Nasti G, Ottaiano A, Pasta G, Belli A. Minimally invasive surgical treatment of intrahepatic cholangiocarcinoma: A systematic review. World J Gastrointest Oncol 2021; 13(12): 2203-2215 [PMID: 35070052 DOI: 10.4251/wjgo.v13.i12.2203]
Corresponding Author of This Article
Andrea Belli, MD, Postdoc, Surgeon, Department of Abdominal Oncology, Division of Hepatobiliary Surgical Oncology, Istituto Nazionale Tumori, Fondazione G. Pascale, IRCCS, Via Mariano Semmola, Naples 80131, Italy. a.belli@istitutotumori.na.it
Research Domain of This Article
Surgery
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Dec 15, 2021; 13(12): 2203-2215 Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.2203
Minimally invasive surgical treatment of intrahepatic cholangiocarcinoma: A systematic review
Renato Patrone, Francesco Izzo, Raffaele Palaia, Vincenza Granata, Guglielmo Nasti, Alessandro Ottaiano, Gilda Pasta, Andrea Belli
Renato Patrone, PhD ICTH, University of Naples Federico II, Naples 80100, Italy
Francesco Izzo, Raffaele Palaia, Andrea Belli, Department of Abdominal Oncology, Division of Hepatobiliary Surgical Oncology, Istituto Nazionale Tumori, Fondazione G. Pascale, IRCCS, Naples 80131, Italy
Vincenza Granata, Division of Radiology, Istituto Nazionale Tumori, Fondazione G. Pascale, IRCCS, Naples 80131, Italy
Guglielmo Nasti, Alessandro Ottaiano, SSD-Innovative Therapies for Abdominal Metastases, Clinical and Experimental Abdominal Oncology, Istituto Nazionale Tumori, Fondazione G. Pascale, IRCCS, Naples 80131, Italy
Gilda Pasta, Division of Anesthesia, Pain medicine and Supportive Care, Istituto Nazionale Tumori, Fondazione G. Pascale, IRCCS, Naples 80131, Italy
Author contributions: All authors contributed significantly to the present research and reviewed the entire manuscript. Patrone R and Belli A participated substantially in the conception, design and execution of the study and in the analysis and interpretation of the data; they also participated substantially in the drafting and editing of the manuscript; Izzo F, Palaia R, Granata V, Nasti G, Ottaiano A and Pasta G participated substantially in the conception, design and execution of the study and in the review of the data.
Conflict-of-interest statement: Authors have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andrea Belli, MD, Postdoc, Surgeon, Department of Abdominal Oncology, Division of Hepatobiliary Surgical Oncology, Istituto Nazionale Tumori, Fondazione G. Pascale, IRCCS, Via Mariano Semmola, Naples 80131, Italy. a.belli@istitutotumori.na.it
Received: March 23, 2021 Peer-review started: March 23, 2021 First decision: May 3, 2021 Revised: May 30, 2021 Accepted: October 31, 2021 Article in press: October 31, 2021 Published online: December 15, 2021 Processing time: 266 Days and 6 Hours
ARTICLE HIGHLIGHTS
Research background
Intrahepatic cholangiocarcinoma represents a very aggressive tumor with poor prognosis. Nowadays surgical open approach is still the gold standard treatment but minimally invasive surgery is gaining an important role. No randomized trials are available on this topic in scientific literature.
Research motivation
Our scientific group aim to contribute to the development of the scientific research on hepatobiliary minimally invasive surgery.
Research objectives
Our research had the objective to summarize and review the scientific evidences present in the literature on minimally invasive surgical approach for intrahepatic cholangiocarcinoma.
Research methods
We performed a systematic review of the literature between 01/01/2009 and 01/01/2021. Our research keywords were: "cholangiocarcinoma", "intrahepatic", "laparoscopic", "surgery", "minimally invasive", "robotic surgery" "biliary neoplasm", "liver resection" and "hepatectomy”. We selected only papers comparing open and laparoscopic approach and reporting at least one intraoperative, postoperative or oncological outcomes.
Research results
We found 9 papers that fulfilled all inclusion criteria reporting data from 3012 patients with no differences in baseline characteristic. Almost all operative outcomes were in favor of laparoscopic groups (blood losses, operative time, hospital stay, post-operative complications) except for the number of lymphonodes retrieved (higher number of lymphonodes retrieved in the open groups). No statistical differences in oncological outcomes were reported.
Research conclusions
Our research demonstrates that very few studies investigated the role of minimally invasive surgery for intrahepatic cholangiocarcinoma. Currently available data in the Literature were not consistent enough to consider the laparoscopic approach to ICC as a standard of care but a steady implementation is likely to be realized in the next future.
Research perspectives
It is likely that soon the diffusion of robotic surgery and tailored surgery, will promote the diffusion of minimally invasive approach for intrahepatic cholangiocarcinoma and will help elucidating its role and the oncological outcomes.
