Immune checkpoint inhibitors induced colitis, stay vigilant: A case report

Figure 1 Endoscopic image of our patient who developed bloody diarrhea within five days of starting immunotherapy, the picture shows his transverse colon which was affected by grade IV severe pancolitis given diffuse erythema, inflammation, ulcers, and some patchy membrane at the proximal colon. Terminal ileum was examined, and it was unremarkable (no picture was included).

Figure 2 Colon mucosa biopsies stained with hematoxylin and eosin showing neutrophilic inflammation with cryptitis and crypt abscess as well as mucin depletion. A: Low power view 10 × highlighting distorted glands; B and C: Medium power view 20 ×, crypt abscess (orange arrow in B) and diffuse inflammation in the background.