Potential microRNA panel for the diagnosis and prediction of overall survival of hepatocellular carcinoma with hepatitis B virus infection

Figure 1 A flow chart of the experimental design. HCC: Hepatocellular carcinoma; HBV: Hepatitis B virus; RT-qPCR: Real time quantitative polymerase chain reaction.

Figure 2 The relative concentration of the selected four miRNAs in the tissue from hepatitis B virus cirrhosis patients and normal controls. A: miR-224; B: miR-122; C: miR-375; D: miR-143. ^cP < 0.001.

Figure 3 Sensitivity and specificity of the four-miRNA and their panel. A: Receiver operating characteristic (ROC) curve of miR-224; B: ROC curve of miR-122; C: ROC curve of miR-375; D: ROC curve of miR-143; E: ROC curve of 4 miR-Panel. ROC: Receiver operating characteristic curves; AUC: Area under curves; HBV: Hepatitis B virus.

Figure 4 Kaplan-Meier curve of relationship between the expression of 4 miRNAs and overall survival of hepatitis B virus cirrhosis. A: Survival of miR-224; B: Survival of miR-122; C: Survival of miR-375; D: Survival of miR-143.