Histo-molecular oncogenesis of pancreatic cancer: From precancerous lesions to invasive ductal adenocarcinoma

Figure 1 Extensive involvement of the pancreas by an intraductal papillary mucinous neoplasm. This neoplasm involves almost all the pancreatic ductal tree. The asterisks indicate Wirsung's duct along its course.

Figure 2 Pancreatic intraepithelial neoplasm precursor lesions. A: High-grade pancreatic intraepithelial neoplasm (PanIN); B: Low-grade PanIN. Original magnification: × 10. Black arrows indicate ducts involved by PanINs.

Figure 3 The four different types of intraductal papillary mucinous neoplasm. A: Gastric; B: Pancreatobiliary; C: Intestinal; D: Oncocytic. Original magnification: A and C: × 10; B and D: × 20. Black arrowheads indicate the fibro-vascular axis of the papillary structures.

Figure 4 Colloid carcinoma with perineural invasion (A, black arrow) and nodal metastasis (B: low magnification; C: higher magnification of the same metastasis). Original magnification: A: × 10; B: × 4; C: × 20.

Figure 5 Mucinous cystic neoplasm precursor lesions. A: Low-grade mucinous cystic neoplasm (MCN); B: High-grade MCN. The black arrow indicates the ovarian-like stroma, a typical component of this type of lesion. Original magnification: × 10.

Figure 6 Intratubular papillary neoplasm precursor lesions. A: Low magnification showing an extensive intraductal growth; B: Higher magnification. Original magnification A: × 1; B: × 4.