Riva G, Pea A, Pilati C, Fiadone G, Lawlor RT, Scarpa A, Luchini C. Histo-molecular oncogenesis of pancreatic cancer: From precancerous lesions to invasive ductal adenocarcinoma. World J Gastrointest Oncol 2018; 10(10): 317-327 [PMID: 30364837 DOI: 10.4251/wjgo.v10.i10.317]
Corresponding Author of This Article
Claudio Luchini, MD, PhD, Assistant Professor, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Piazzale L.A. Scuro, 10, Verona 37134, Italy. claudio.luchini@univr.it
Research Domain of This Article
Pathology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Giulio Riva, Giulia Fiadone, Aldo Scarpa, Claudio Luchini, Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona 37134, Italy
Antonio Pea, Department of Surgery, University and Hospital trust of Verona, Verona 37134, Italy
Camilla Pilati, Personalized Medicine, Pharmacogenomics, Therapeutic Optimization, Paris-Descartes University, Paris 75006, France
Rita Teresa Lawlor, ARC-Net Research Center, University and Hospital Trust of Verona, Verona 37134, Italy
Author contributions: Luchini C, Scarpa A and Lawlor RT conceived and designed the study; Riva G, Pea A, Lawlor RT and Luchini C performed the literature review; all authors analyzed and interpreted literature; Riva G, Pea A, Scarpa A and Luchini C wrote the manuscript; all authors edited and approved the manuscript in its present form.
Supported bythe Associazione Italiana Ricerca sul Cancro, No. 12182; and Cassini Project.
Conflict-of-interest statement: No potential conflict of interest.
Open-Access: This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Claudio Luchini, MD, PhD, Assistant Professor, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Piazzale L.A. Scuro, 10, Verona 37134, Italy. claudio.luchini@univr.it
Telephone: +39-45-8124835 Fax: +39-45-8027136
Received: May 30, 2018 Peer-review started: May 30, 2018 First decision: July 3, 2018 Revised: July 13, 2018 Accepted: August 12, 2018 Article in press: August 13, 2018 Published online: October 15, 2018 Processing time: 138 Days and 5.8 Hours
Abstract
Pancreatic cancer is a lethal malignancy, whose precursor lesions are pancreatic intraepithelial neoplasm, intraductal papillary mucinous neoplasm, intraductal tubulopapillary neoplasm, and mucinous cystic neoplasm. To better understand the biology of pancreatic cancer, it is fundamental to know its precursors and to study the mechanisms of carcinogenesis. Each of these precursors displays peculiar histological features, as well as specific molecular alterations. Starting from such pre-invasive lesions, this review aims at summarizing the most important aspects of carcinogenesis of pancreatic cancer, with a specific focus on the recent advances and the future perspectives of the research on this lethal tumor type.
Core tip: Pancreatic intraepithelial neoplasm, intraductal papillary mucinous neoplasm, intraductal tubulopapillary neoplasm, and mucinous cystic neoplasm are precursor lesions of invasive pancreatic cancer. Each of these precursors displays peculiar histological and molecular features, which have been summarized in this review along with the most important aspects of pancreatic carcinogenesis. The most recent advances and the future perspectives of the research on this topic have also been highlighted.
