Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2017; 9(9): 390-396
Published online Sep 15, 2017. doi: 10.4251/wjgo.v9.i9.390
Published online Sep 15, 2017. doi: 10.4251/wjgo.v9.i9.390
Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in a CDKN2A germline mutation carrier
Fernando Martínez de Juan, María Reolid Escribano, Carmen Martínez Lapiedra, Fernanda Maia de Alcantara, Gastroenterology and Digestive Endoscopy Department, Valencian Institute of Oncology, 46009 Valencia, Spain
María Caballero Soto, Digestive Surgery Department, Valencian Institute of Oncology, 46009 Valencia, Spain
Ana Calatrava Fons, Isidro Machado, Pathology Department, Valencian Institute of Oncology, 46009 Valencia, Spain
Author contributions: Martínez de Juan F and Machado I wrote the paper and contributed equally to this work; Reolid Escribano M, Martínez Lapiedra C and Maia de Alcantara F collected the clinical data and endoscopy ultrasound images and made a critical revision of the paper; Calatrava Fons A collected the cytology images and made a critical revision of the paper; Caballero Soto M collected the data referred to the surgical details and made a critical revision of the paper.
Institutional review board statement: The study was reviewed and approved by the Clinical Investigation Ethical Board.
Informed consent statement: All study participants, or their legal guardian provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare non conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fernando Martínez de Juan, MD, Gastroenterology and Digestive Endoscopy Department, Valancian Institute of Oncology, Calle Profesor Beltrán Báguena, 8. 46009 Valencia, Spain. fmartinezj@fivo.org
Telephone: +34-96-1114005 Fax: +34-96-1114341
Received: December 12, 2016
Peer-review started: December 14, 2016
First decision: March 22, 201
Revised: April 20, 2017
Accepted: July 14, 2017
Article in press: July 17, 2017
Published online: September 15, 2017
Peer-review started: December 14, 2016
First decision: March 22, 201
Revised: April 20, 2017
Accepted: July 14, 2017
Article in press: July 17, 2017
Published online: September 15, 2017
Core Tip
Core tip: We present a rare case of adenosquamous pancreatic carcinoma (ASPC) arising in an intraductal papillar mucinous neoplasm in a CDKN2A germline mutation carrier from a kindred with familial atypical multiple mole melanoma. The case is an accelerated model of the adenoma-carcinoma sequence in pancreatic carcinogenesis. We discuss the differential diagnoses of squamous lesions in the pancreas and review the clinical and morphological features of ASPC.