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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2017; 9(9): 379-384
Published online Sep 15, 2017. doi: 10.4251/wjgo.v9.i9.379
Published online Sep 15, 2017. doi: 10.4251/wjgo.v9.i9.379
Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer
Giammaria Fiorentini, Donatella Sarti, Onco-Hematology Department, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, 61122 Pesaro, Italy
Riccardo Carandina, Camillo Aliberti, Oncology Radiodiagnostics Department, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer, 35128 Padova, Italy
Michele Nardella, Riccardo Inchingolo, Massimiliano Nestola, Diagnostic and Interventtional Radiology Department, Ospedale Madonna delle Grazie, 75100 Matera, Italy
Odysseas Zoras, Surgical Oncology University of Crete, ESSO Board of Directors Member, Rector of the University, Voutes Campus, Heraklion, 71003 Crete, Greece
Stefano Guadagni, Department of Applied Clinical Sciences and Biotechnology, Section of General Surgery, University of L’Aquila, 67100 L’Aquila, Italy
Alessandro Felicioli, Diagnostic and Interventtional Radiology Department, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, 61122 Pesaro, Italy
Daniel Barnes Navarro, Interventional Radiology Department, Hospital Clínic de Barcelona, 08036 Barcelona, Spain
Author contributions: Fiorentini G and Sarti D wrote the paper and made tables and figures; Carandina R, Nardella M, Inchingolo R, Nestola M, Felicioli A, Barnes Navarro D, Munos Gomez F and Aliberti C collected the data; Zoras O and Guadagni S supervised the study.
Institutional review board statement: The study was reviewed and approved by the Azienda Ospedaliera “Ospedali Riuniti Marche Nord” Institutional Review Board.
Clinical trial registration statement: This study is registered at https://clinicaltrials.gov. This was part of the study: ClinicalTrials.gov Identifier: NCT01891552.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Giammaria Fiorentini, Onco-Hematology Department, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, Via Lombroso 1, 61122 Pesaro, Italy. g.fiorentini@alice.it
Telephone: +39-721-364005
Received: May 11, 2017
Peer-review started: May 11, 2017
First decision: May 23, 2017
Revised: May 24, 2017
Accepted: June 30, 2017
Article in press: July 3, 2017
Published online: September 15, 2017
Processing time: 123 Days and 0.5 Hours
Peer-review started: May 11, 2017
First decision: May 23, 2017
Revised: May 24, 2017
Accepted: June 30, 2017
Article in press: July 3, 2017
Published online: September 15, 2017
Processing time: 123 Days and 0.5 Hours
Core Tip
Core tip: Patients with liver metastases from colorectal cancer are in 80% of cases non-indicated for resection. The standard first line treatment of unresectable liver metastases is systemic chemotherapy, however this method results in progression for 70% of patients. The indicated therapy for refractory patients is the chemoembolization. In this study, we monitored tumor response, and adverse events after chemoembolization of colorectal cancer liver metastases with polyethylene glycol embolics loaded with irinotecan. Chemoembolization with these embolics is effective in terms of tumor response, time to progression, survival and quality of life and resulted in mild toxicity.