Retrospective Cohort Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2017; 9(7): 300-307
Published online Jul 15, 2017. doi: 10.4251/wjgo.v9.i7.300
Prognostic efficacy of inflammation-based markers in patients with curative colorectal cancer resection
Özgür Akgül, Erdinç Çetinkaya, Metin Yalaza, Sabri Özden, Mesut Tez
Özgür Akgül, Erdinç Çetinkaya, Metin Yalaza, Sabri Özden, Mesut Tez, General Surgery Department, Ankara Numune Training and Research Hospital, 06100 Ankara, Turkey
Author contributions: Akgül Ö and Tez M designed the study; Akgül Ö, Çetinkaya E, Yalaza M and Özden S collected the data from the patients; Akgül Ö and Çetinkaya E drafted the initial manuscript; Tez M supervised the study, analysed the data, and critically reviewed the manuscript; all authors approved the final manuscript as submitted.
Institutional review board statement: Due to the retrospective nature of the study, approval from an institutional review board was not obtained.
Informed consent statement: The data retrospectively collected and anonymized.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at drozgurakgul@gmail.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Özgür Akgül, General Surgery Department, Ankara Numune Training and Research Hospital, 06100 Ankara, Turkey. drozgurakgul@gmail.com
Telephone: +90-505-7924983 Fax: +90-312-5084312
Received: November 7, 2016
Peer-review started: November 8, 2016
First decision: December 27, 2016
Revised: January 19, 2017
Accepted: March 23, 2017
Article in press: March 24, 2017
Published online: July 15, 2017
Processing time: 246 Days and 15.2 Hours
Core Tip

Core tip: Predictors of colorectal cancer (CRC) that may determine overall survival are extremely important. Inflammation is now widely recognised to be a key element of disease advancement and survival in CRC. Aim of this study was to evaluate the prognostic significance of clinicopathologic factors and the indicators of systematic inflammatory response by using neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and prognostic nutritional index in patients undergoing curative resection of colon cancer. In the present study, we report, for the first time, a longitudinal comparison of the four systemic inflammation-based prognostic scores and CA19-9 in patients with resectable CRC.