Retrospective Cohort Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2017; 9(11): 436-443
Published online Nov 15, 2017. doi: 10.4251/wjgo.v9.i11.436
Paradoxical expression pattern of the epithelial mesenchymal transition-related biomarkers CD44, SLUG, N-cadherin and VSIG1/Glycoprotein A34 in gastrointestinal stromal tumors
Attila Kövecsi, Simona Gurzu, Zoltan Szentirmay, Zsolt Kovacs, Tivadar Jr Bara, Ioan Jung
Attila Kövecsi, Simona Gurzu, Zsolt Kovacs, Ioan Jung, Department of Pathology, University of Medicine and Pharmacy, Tirgu Mures 540139, Romania
Simona Gurzu, Research Center, University of Medicine and Pharmacy, Timi oara 3000041, Romania
Zoltan Szentirmay, Department of Pathology, National Institute of Oncology, Budapest 1525, Hungary
Zsolt Kovacs, Department of Biochemistry, University of Medicine and Pharmacy, Timi oara 3000041, Romania
Tivadar Jr Bara, Department of Surgery, University of Medicine and Pharmacy, Timi oara 3000041, Romania
Author contributions: Kovecsi A drafted the article and contributed to interpretation of the immunostains; Gurzu S designed research and contributed to the diagnosis and statistical assessment; Szentirmay Z performed the molecular examinations; Kovacs Z contributed to the molecular examinations; Bara T Jr performed the surgical interventions; Bara T Jr participated at the surgical interventions and the clinical assessment of the cases; Jung I performed the interpretation of the immunohistochemical stains and confer the final agreement for publication; Kövecsi A and Bara T Jr have equal contribution to the paper.
Supported by University of Medicine and Pharmacy of Tirgu-Mures, Romania, in the joint project with Studium Prospero Foundation and Hungarian Science Academy, research projects frame 136/2017.
Conflict-of-interest statement: None declared.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Simona Gurzu, MD, PhD, Professor, Head of Department of Pathology, University of Medicine and Pharmacy, Gheorghe Marinescu 38 street, Tirgu Mures 540139, Romania.
Telephone: +40-745-673550 Fax: +40-265-210407
Received: May 29, 2017
Peer-review started: June 6, 2017
First decision: July 26, 2017
Revised: July 31, 2017
Accepted: September 5, 2017
Article in press: September 6, 2017
Published online: November 15, 2017
Core Tip

Core tip: In this paper we proved for the first time in the current literature the possible role of V-set and immunoglobulin domain containing 1 (VSIG1) in gastrointestinal stromal tumors (GISTs) in correlation with the expression of the other markers involved in the epithelial mesenchymal/mesenchymal epithelial transition. Based on the obtained results, we hypothesized that the GIST aggressivity may be induced by nuclear upregulation of SLUG and the loss or cytoplasm-to-nuclear translocation of VSIG1.