Retrospective Cohort Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2016; 8(7): 543-549
Published online Jul 15, 2016. doi: 10.4251/wjgo.v8.i7.543
Opioid-sparing effect of selective cyclooxygenase-2 inhibitors on surgical outcomes after open colorectal surgery within an enhanced recovery after surgery protocol
Varut Lohsiriwat
Varut Lohsiriwat, Division of Colon and Rectal Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Author contributions: Lohsiriwat V solely contributed to this article.
Institutional review board statement: The study was reviewed and approved by the Siriraj Institutional Review Board (SIRB COA No. Si014/2013).
Informed consent statement: As the study is a retrospective review, a waiver of informed consent was approved by the Siriraj Institutional Review Board.
Conflict-of-interest statement: Varut Lohsiriwat has received fees for serving as a speaker for Pfizer, MSD and Johnson and Johnson (Thailand) Limited.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at bolloon@hotmail.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Varut Lohsiriwat, MD, PhD, Associate Professor of Surgery, Division of Colon and Rectal Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang-Lung Road, Bangkok Noi, Bangkok 10700, Thailand. bolloon@hotmail.com
Telephone: +66-2-4198005Fax: +66-2-4121370
Received: February 21, 2016
Peer-review started: March 2, 2016
First decision: April 6, 2016
Revised: April 9, 2016
Accepted: April 21, 2016
Article in press: April 22, 2016
Published online: July 15, 2016
Processing time: 129 Days and 7.5 Hours
Core Tip

Core tip: This comparative study validates the effectiveness of perioperative administration of oral selective cyclooxygenase-2 (COX-2) inhibitors as a part of multimodal analgesia in an enhanced recovery after surgery protocol to significantly reduce opioid requirement (but not pain score) after open colorectal surgery. Our findings also indicate that opioid-sparing effect of selective COX-2 inhibitor has some important clinical benefits including quicker gastrointestinal recovery and shorter hospitalization.