Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2016; 8(6): 509-519
Published online Jun 15, 2016. doi: 10.4251/wjgo.v8.i6.509
Genetic risks and familial associations of small bowel carcinoma
Santosh Shenoy
Santosh Shenoy, Department of Surgery, KCVA, University of Missouri at Kansas City, Kansas, MO 64128, United States
Author contributions: Shenoy S collected the data, wrote, and revised the manuscript.
Conflict-of-interest statement: There is no conflict of interest, no funding or financial disclosures.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Santosh Shenoy, MD, FACS, Department of Surgery, KCVA, University of Missouri at Kansas City, 4801 E Linwood Blvd, Kansas, MO 64128, United States.
Telephone: +1-816-8614700-55431 Fax: +1-816-9224609
Received: December 23, 2015
Peer-review started: December 24, 2015
First decision: January 30, 2016
Revised: February 2, 2016
Accepted: March 14, 2016
Article in press: March 16, 2016
Published online: June 15, 2016
Core Tip

Core tip: Adenocarcinoma of small intestine (SBA) is a relatively rare malignancy with poor outcomes due to delayed diagnosis. Certain genetic and familial diseases are associated with increased risks for SBA. These include Familial adenomatous polyposis, lynch syndromes, juvenile polyposis syndrome, Peutz-Jeghers syndrome, Crohn’s disease and celiac disease. We discuss the clinical implications of this aggressive cancer focusing on the genetic and familial associations, signaling mechanisms and available diagnostic modalities for surveillance.