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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2016; 8(3): 305-313
Published online Mar 15, 2016. doi: 10.4251/wjgo.v8.i3.305
Published online Mar 15, 2016. doi: 10.4251/wjgo.v8.i3.305
Expression of p-STAT3 and vascular endothelial growth factor in MNNG-induced precancerous lesions and gastric tumors in rats
Xiao-Yan Wang, Lou-Lei Wang, the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Xuan Zheng, Li-Na Meng, Bin Lyu, Hai-Feng Jin, the First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Wang XY and Wang LL are co-first authors; they contributed equally to the work; Zheng X, Meng LN, Lyu B and Jin HF contributed to the conception and design of the study, acquisition, analysis and interpretation of data; all authors drafted the article and made critical revisions related to the intellectual content of the manuscript, and approved the final version of the article to be published.
Institutional animal care and use committee statement: The Animal Care and Use Committee of the First Affiliated Hospital of Zhejiang Chinese Medicine University approved the protocol.
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hai-Feng Jin, MD, Resident Physician of Gastroenterology, the First Affiliated Hospital of Zhejiang Chinese Medicine University, Youdian Rd. 54, Hangzhou 310006, Zhejiang Province, China. jinhaifeng0908@163.com
Telephone: +86-571-87077785 Fax: +86-571-87077785
Received: June 16, 2015
Peer-review started: June 19, 2015
First decision: October 21, 2015
Revised: November 14, 2015
Accepted: January 21, 2016
Article in press: January 22, 2016
Published online: March 15, 2016
Peer-review started: June 19, 2015
First decision: October 21, 2015
Revised: November 14, 2015
Accepted: January 21, 2016
Article in press: January 22, 2016
Published online: March 15, 2016
Core Tip
Core tip: The results show that signal transducer and activator of transcription 3 (STAT3) is partially responsible for the progression from chronic gastritis to gastric carcinoma induced by N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) and is significantly related to the expression of vascular endothelial growth factor (VEGF) during this process. It is considered that STAT3 induces an abnormal level of VEGF expression to promote the formation of gastric carcinoma. To the best of our knowledge, this is the first report to show that p-STAT3 is persistently activated during the progression of chronic gastritis to gastritis carcinoma induced by the administration of MNNG in rats, and was positively associated with the expression of VEGF.