Lo Nigro C, Ricci V, Vivenza D, Monteverde M, Strola G, Lucio F, Tonissi F, Miraglio E, Granetto C, Fortunato M, Merlano MC. Evaluation of antibody-dependent cell-mediated cytotoxicity activity and cetuximab response in KRAS wild-type metastatic colorectal cancer patients. World J Gastrointest Oncol 2016; 8(2): 222-230 [PMID: 26909137 DOI: 10.4251/wjgo.v8.i2.222]
Corresponding Author of This Article
Cristiana Lo Nigro, PhD, Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce and Carle Teaching Hospital, Via Carle 25, 12100 Cuneo, Italy. lonigro.c@ospedale.cuneo.it
Research Domain of This Article
Oncology
Article-Type of This Article
Evidence-Based Medicine
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Feb 15, 2016; 8(2): 222-230 Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.222
Evaluation of antibody-dependent cell-mediated cytotoxicity activity and cetuximab response in KRAS wild-type metastatic colorectal cancer patients
Cristiana Lo Nigro, Vincenzo Ricci, Daniela Vivenza, Martino Monteverde, Giuliana Strola, Francesco Lucio, Federica Tonissi, Emanuela Miraglio, Cristina Granetto, Mirella Fortunato, Marco Carlo Merlano
Cristiana Lo Nigro, Daniela Vivenza, Martino Monteverde, Federica Tonissi, Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce and Carle Teaching Hospital, 12100 Cuneo, Italy
Vincenzo Ricci, Emanuela Miraglio, Cristina Granetto, Marco Carlo Merlano, Medical Oncology, Oncology Department, S. Croce and Carle Teaching Hospital, 12100 Cuneo, Italy
Giuliana Strola, Laboratory Department, S. Croce and Carle Teaching Hospital, 12100 Cuneo, Italy
Francesco Lucio, Radiotherapy Department, S. Croce and Carle Teaching Hospital, 12100 Cuneo, Italy
Mirella Fortunato, Pathology Department, S. Croce and Carle Teaching Hospital, 12100 Cuneo, Italy
Author contributions: Lo Nigro C, Ricci V and Merlano MC designed the study; Ricci V, Miraglio E and Granetto C enrolled the patients and collected clinical data; Vivenza D, Monteverde M and Tonissi F performed ADCC assays and genotyping analyses; Strola G performed all the cytofluorimetric studies; Fortunato M selected patient’s tumoral samples; Vivenza D and Lucio F performed the statistical analysis; Lo Nigro C, Ricci V and Merlano MC critically visioned the results and were equally involved in the writing of the paper with Vivenza D.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Cristiana Lo Nigro, PhD, Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce and Carle Teaching Hospital, Via Carle 25, 12100 Cuneo, Italy. lonigro.c@ospedale.cuneo.it
Telephone: +39-0171-616338 Fax: +39-0171-616331
Received: July 29, 2015 Peer-review started: July 31, 2015 First decision: September 29, 2015 Revised: November 27, 2015 Accepted: December 9, 2015 Article in press: December 11, 2015 Published online: February 15, 2016 Processing time: 188 Days and 19.1 Hours
Core Tip
Core tip: A high number of invariant natural killer T (iNKT) cells and a high antibody-dependent cell-mediated cytotoxicity (ADCC) activity, evaluated before therapy, do correlate significantly with a longer overall survival in metastatic colorectal cancer patients treated with irinotecan-based chemotherapy and cetuximab in II and III lines. Chemotherapy impacted both iNKT cells and ADCC activity. The prognostic value of ADCC above the median basal level, get lost when we analysed those parameters after 2 and 4 mo of treatment. Correlation of overall survival and progression-free survival with interesting single nucleotide polymorphisms reported as involved in ADCC ability, either in the FCGR2A, FCGR3A or in the 3’ untranslated regions of KRAS gene, revealed not to be significant.
