Case Control Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2016; 8(2): 207-214
Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.207
Risk factors for the development of colorectal carcinoma: A case control study from South India
Santhana Krishnan Iswarya, Kariyarath Cheriyath Premarajan, Sitanshu Sekhar Kar, Sathasivam Suresh Kumar, Vikram Kate
Santhana Krishnan Iswarya, Kariyarath Cheriyath Premarajan, Sitanshu Sekhar Kar, Departments of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Sathasivam Suresh Kumar, Vikram Kate, Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Author contributions: Iswarya SK, Premarajan KC and Kate V designed the research; Iswarya SK collected data; Iswarya SK, Kar SS and Kumar SS analyzed the data and prepared the manuscript; Premarajan KC, Kumar SS and Kate V corrected and revised the manuscript; and Kate V is the guarantor.
Institutional review board statement: The study was reviewed and approved by the JIPMER Institute Human Ethics Committee.
Informed consent statement: All patients gave informed written consent to participate in the study before enrollment.
Conflict-of-interest statement: No benefits in any form have been received or will be received from any party related directly or indirectly to the subject of this article.
Data sharing statement: Technical appendix, statistical code and dataset available with the corresponding author at drvikramkate@gmail.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Vikram Kate, MS, FRCS (Eng.), FRCS (Ed.), FRCS (Glasg.), PhD, MAMS, FIMSA, MASCRS, FACS, FACG, MFSTEd, Professor of General and Gastrointestinal Surgery, Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Temple Road, Dhanvantri Nagar, Pondicherry 605006, India. drvikramkate@gmail.com
Telephone: +91-413-2296741 Fax: +91-413-2272066
Received: June 6, 2015
Peer-review started: June 8, 2015
First decision: August 26, 2015
Revised: September 15, 2015
Accepted: November 13, 2015
Article in press: November 13, 2015
Published online: February 15, 2016
Processing time: 240 Days and 21 Hours
Core Tip

Core tip: In this hospital based case control study, egg consumption of 2-3 times a week and red meat consumption of 2-3 times a month were found to be independent risk factors for the development of colorectal carcinoma. On the other hand smoking, alcohol, physical activity, diabetes and family history were not associated with an increased risk. There was no conclusive evidence to suggest that fruits and vegetable consumption has protective effect on colorectal carcinoma. Since red meat and egg had an increased risk, the community needs to be educated to reduce the consumption of red meat such as mutton and egg.