Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2015; 7(4): 17-29
Published online Apr 15, 2015. doi: 10.4251/wjgo.v7.i4.17
Cancer cachexia, mechanism and treatment
Tomoyoshi Aoyagi, Krista P Terracina, Ali Raza, Hisahiro Matsubara, Kazuaki Takabe
Tomoyoshi Aoyagi, Krista P Terracina, Ali Raza, Kazuaki Takabe, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, VA 23298-0011, United States
Tomoyoshi Aoyagi, Hisahiro Matsubara, Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba 263-0022, Japan
Author contributions: All the authors generated the ideas and contributed to the writing of this paper.
Supported by NIH, No. R01CA160688 and No. T32CA085159-10.
Conflict-of-interest: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kazuaki Takabe, MD, PhD, FACS, Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, West Hospital 7-402, 1200 East Broad Street, Richmond, VA 23298-0011, United States. ktakabe@vcu.edu
Telephone: +1-804-8289322 Fax: +1-804-8284808
Received: October 21, 2014
Peer-review started: October 25, 2014
First decision: December 17, 2014
Revised: January 17, 2015
Accepted: March 30, 2015
Article in press: April 2, 2015
Published online: April 15, 2015
Core Tip

Core tip: This review aims to present the clinical presentation, the mechanisms, and current treatment options, such as pharmacological treatment and physical exercise for cancer cachexia.