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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2015; 7(12): 513-523
Published online Dec 15, 2015. doi: 10.4251/wjgo.v7.i12.513
Published online Dec 15, 2015. doi: 10.4251/wjgo.v7.i12.513
Management of asymptomatic primary tumours in stage IV colorectal cancer: Review of outcomes
Kate Jessica Wilkinson, Wei Chua, Weng Ng, Aflah Roohullah, Liverpool Cancer Therapy Centre, Liverpool Hospital, Liverpool, NSW 2170, Australia
Author contributions: Wilkinson KJ and Roohullah A designed the research; Wilkinson KJ performed the research; Wilkinson KJ, Roohullah A, Chua W and Ng W analyzed the data and wrote the paper.
Conflict-of-interest statement: No conflicts of interest are declared by the authors.
Data sharing statement: All data referred to in this review is taken directly from the outcome data from the original cited papers. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Kate Jessica Wilkinson, MBChB, Medical Oncology Advanced Trainee, Liverpool Cancer Therapy Centre, Liverpool Hospital, Corner of Elizabeth and Goulburn Streets, Liverpool, NSW 2170, Australia. kate.wilkinson@sswahs.nsw.gov.au
Telephone: +61-2-87389744 Fax: +61-2-87389811
Received: April 26, 2015
Peer-review started: April 28, 2015
First decision: September 8, 2015
Revised: September 23, 2015
Accepted: November 3, 2015
Article in press: November 4, 2015
Published online: December 15, 2015
Processing time: 232 Days and 2.1 Hours
Peer-review started: April 28, 2015
First decision: September 8, 2015
Revised: September 23, 2015
Accepted: November 3, 2015
Article in press: November 4, 2015
Published online: December 15, 2015
Processing time: 232 Days and 2.1 Hours
Core Tip
Core tip: The management of asymptomatic primary tumours in stage IV colorectal cancer is under debate. A literature review was performed focusing on this cohort, with patients undergoing primary tumour resection (PTR) vs up front chemotherapy. Survival appears equivalent with both management strategies, with a trend to an advantage in PTR. Surgical mortality is low and most morbidity transient. Most studies are retrospective, small and non-randomised. Larger randomised controlled trials are awaited.