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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2015; 7(12): 455-465
Published online Dec 15, 2015. doi: 10.4251/wjgo.v7.i12.455
Published online Dec 15, 2015. doi: 10.4251/wjgo.v7.i12.455
Helicobacter pylori in gastric carcinogenesis
Hyo Jun Ahn, Dong Soo Lee, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. Mary’s Hospital, the Catholic University of Korea, Daejeon 301-723, South Korea
Author contributions: Ahn HJ and Lee DS equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: The authors have no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dong Soo Lee, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Daejeon St. Mary’s Hospital, the Catholic University of Korea, Daeheung-ro 64, Jung-gu, Daejeon 301-723, South Korea. endoscope@hanmail.net
Telephone: +82-42-2209294
Received: June 27, 2015
Peer-review started: June 27, 2015
First decision: July 25, 2015
Revised: October 10, 2015
Accepted: November 3, 2015
Article in press: November 4, 2015
Published online: December 15, 2015
Processing time: 170 Days and 11.1 Hours
Peer-review started: June 27, 2015
First decision: July 25, 2015
Revised: October 10, 2015
Accepted: November 3, 2015
Article in press: November 4, 2015
Published online: December 15, 2015
Processing time: 170 Days and 11.1 Hours
Core Tip
Core tip:Helicobacter pylori (H. pylori) is an important etiologic agent in gastric carcinogenesis. Here, we summarize not only recently investigated mechanisms of virulence factors, host genetic factors, and environmental factors, but also potential prevention. The best preventive methods in H. pylori-induced carcinogenesis may be achieved through H. pylori eradication, dietary, or lifestyle modifications, as well as a better understanding of molecular pathogenesis.