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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2015; 7(11): 328-337
Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.328
Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.328
Polymorphisms in mucin genes in the development of gastric cancer
Rong Wen, Fang Gao, Cheng-Jiang Zhou, Yan-Bin Jia, School of Basic Medicine, Baotou Medical College, Baotou 014060, Inner Mongolia Autonomous Region, China
Yan-Bin Jia, Inner Mongolia Institute of Digestive Diseases, the Second Affiliated Hospital of Baotou Medical College, Baotou 014030, Inner Mongolia Autonomous Region, China
Author contributions: All authors contributed to this work.
Supported by National Natural Science Foundation of China, No. 30960169 and No. 81250024; Natural Science Foundation of Inner Mongolia, No. 2011MS1103; and Inner Mongolian Committee of Science and Technology, China, No. 20110501.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this paper.
Open-Access: This article is an open-access article which selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yan-Bin Jia, Professor, School of Basic Medicine, Baotou Medical College, 31 Jianshe Road, Donghe District, Baotou 014060, Inner Mongolia Autonomous Region, China. jyb690318@hotmail.com
Telephone: +86-472-7167832 Fax: +86-472-7167739
Received: April 25, 2015
Peer-review started: April 26, 2015
First decision: June 2, 2015
Revised: July 1, 2015
Accepted: August 30, 2015
Article in press: September 7, 2015
Published online: November 15, 2015
Peer-review started: April 26, 2015
First decision: June 2, 2015
Revised: July 1, 2015
Accepted: August 30, 2015
Article in press: September 7, 2015
Published online: November 15, 2015
Core Tip
Core tip:Helicobacter pylori (H. pylori) infection is the single most important risk factor in the development of gastric cancer (GC), however the etiology of GC involves host and other environmental factors. Genetic and biological evidence highlights the important roles of variations in mucin genes in the development and progression of GC. In this review, we summarize studies of the association between polymorphisms in MUC1, MUC5AC, MUC6 and MUC2 and development of GC, which should be helpful for the early detection, surveillance, and treatment of GC.