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Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2015; 7(10): 250-258
Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.250
Genomic alterations in pancreatic cancer and their relevance to therapy
Erina Takai, Shinichi Yachida
Erina Takai, Shinichi Yachida, Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo 104-0045, Japan
Author contributions: Takai E performed the majority of the writing and prepared the figure; Yachida S designed the outline and supervised the writing of the paper.
Supported by Grants-in Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan, No. 26870874 to Takai E and No. 25134719 to Yachida S; the National Cancer Center Research and Development Fund (25-A-3 to Takai E and Yachida S); the Takeda Science Foundation (Yachida S); the Uehara Memorial Foundation (Yachida S); the Mochida Memorial Foundation for Medical and Pharmaceutical Research (Yachida S); the Medical Research Encouragement Prize of the Japan Medical Association (Yachida S); the Pancreas Research Foundation of Japan (Yachida S); Princess Takamatsu Cancer Research Fund (Yachida S).
Conflict-of-interest statement: There is no conflict of interest associated with any of the authors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Erina Takai, PhD, Division of Cancer Genomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ertakai@ncc.go.jp
Telephone: +81-3-35422511 Fax: +81-3-35453567
Received: May 1, 2015
Peer-review started: May 8, 2015
First decision: July 17, 2015
Revised: July 28, 2015
Accepted: September 10, 2015
Article in press: September 16, 2015
Published online: October 15, 2015
Processing time: 171 Days and 0.3 Hours
Core Tip

Core tip: With the advance of sequencing technologies for global genomic analysis, the landscape of genomic alterations in pancreatic cancer is becoming increasingly well understood. In this review, we summarize the latest knowledge of genomic alterations in pancreatic ductal adenocarcinoma including commonly mutated genes and many other genes that are mutated at low frequencies. We also describe the potential implications of these genomic alterations for development of novel therapeutic approaches in the context of personalized medicine.