Review
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World J Gastrointest Oncol. Jun 15, 2014; 6(6): 156-169
Published online Jun 15, 2014. doi: 10.4251/wjgo.v6.i6.156
Primary tumor resection in colorectal cancer with unresectable synchronous metastases: A review
Louis de Mestier, Gilles Manceau, Cindy Neuzillet, Jean Baptiste Bachet, Jean Philippe Spano, Reza Kianmanesh, Jean Christophe Vaillant, Olivier Bouché, Laurent Hannoun, Mehdi Karoui
Louis de Mestier, Olivier Bouché, Department of Gastroenterology and Digestive Oncology, Robert-Debré University Hospital, 51100 Reims, France
Gilles Manceau, Jean Christophe Vaillant, Laurent Hannoun, Mehdi Karoui, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Digestive and Hepato-Pancreato-Biliary Surgery, University Institute of Cancerology (Paris VI), Pierre and Marie Curie University, 75013 Paris, France
Cindy Neuzillet, Assistance Publique-Hôpitaux de Paris, Department of Gastroenterology and Pancreatology, Beaujon University Hospital, 92110 Clichy, France
Jean Baptiste Bachet, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Gastroenterology, University Institute of Cancerology (Paris VI), Pierre and Marie Curie University, 75013 Paris, France
Jean Philippe Spano, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Medical Oncology, University Institute of Cancerology (Paris VI), Pierre and Marie Curie University, 75013 Paris, France
Reza Kianmanesh, Department of Digestive and Endocrine Surgery, Robert-Debré University Hospital, 51100 Reims, France
Author contributions: de Mestier L, Manceau G, Neuzillet C, Bachet JB, Spano JP, Kianmanesh R, Vaillant JC, Bouché O, Hannoun L and Karoui M designed research; de Mestier L, Manceau G, Karoui M performed research; de Mestier L, Manceau G and Karoui M analyzed data; de Mestier L, Manceau G, Neuzillet C, Bachet JB, Spano JP, Kianmanesh R, Vaillant JC, Bouché O, Hannoun L and Karoui M wrote the paper.
Correspondence to: Mehdi Karoui, MD, PhD, Professor of Surgery, Assistance Publique-Hôpitaux de Paris, Pitié Salpêtrière University Hospital, Department of Digestive and Hepato-Pancreato-Biliary Surgery, University Institute of Cancerology (Paris VI), Pierre and Marie Curie University, 47-83 Boulevard de l’Hôpital, 75013 Paris, France. mehdi.karoui@psl.aphp.fr
Telephone: +33-1-42175612 Fax: +33-1-42175613
Received: November 17, 2013
Revised: April 8, 2014
Accepted: May 13, 2014
Published online: June 15, 2014
Processing time: 215 Days and 12.8 Hours
Core Tip

Core tip: The present review aimed to analyze all published data on whether primary tumor resection should be performed before chemotherapy administration in patients with colorectal cancer and unresectable synchronous metastases.