Copyright
©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2014; 6(3): 67-73
Published online Mar 15, 2014. doi: 10.4251/wjgo.v6.i3.67
Published online Mar 15, 2014. doi: 10.4251/wjgo.v6.i3.67
Xenoestrogens challenge 17β-estradiol protective effects in colon cancer
Maria Marino, Department of Science, University Roma Tre, I-00146 Roma, Italy
Author contributions: Marino M solely contributed to this paper.
Supported by University Roma Tre
Correspondence to: Maria Marino, PhD, Professor, Department of Science, University Roma Tre, Viale G. Marconi 446, I-00146 Roma, Italy. maria.marino@uniroma3.it
Telephone: +39-6-57336345 Fax: +39-6-57336321
Received: November 21, 2013
Revised: January 10, 2014
Accepted: February 16, 2014
Published online: March 15, 2014
Revised: January 10, 2014
Accepted: February 16, 2014
Published online: March 15, 2014
Core Tip
Core tip: In this review, we will report recent data, including ours, on 17β-estradiol (E2) action in colon health and disease discussing on how environmental chemicals with endocrine disrupting activities could impact on these E2 effects in colon cancer. In particular, two plant-derived flavonoids (i.e., naringenin, Nar, and quercetin, Que) and one synthetic food-contaminant bisphenol A will be reported as prototype molecules to evaluate how xenoestrogens can impact on cell proliferation/apoptosis balance, the critical physiological function of E2 in colon.