Vitamin D and colon cancer

doi:10.4251/wjgo.v6.i11.430

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769

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Nov 15, 2014 (publication date) through Nov 4, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Nov 15, 2014; 6(11): 430-437
Published online Nov 15, 2014. doi: 10.4251/wjgo.v6.i11.430

Vitamin D and colon cancer

Lidija Klampfer

Lidija Klampfer, Southern Research Institute, Birmingham, AL 35205, United States

Author contributions: Klampfer L solely contributed to this paper.

Correspondence to: Lidija Klampfer, PhD, Southern Research Institute, 2000 9^th Avenue, Birmingham, AL 35205, United States. klampfer@southernresearch.org

Telephone: +1-205-5812731

Received: May 22, 2014
Revised: July 31, 2014
Accepted: September 23, 2014
Published online: November 15, 2014

Core Tip

Core tip: Epidemiological studies suggest that deficiency of vitamin D increases the incidence of colon cancer and also has a negative impact on the survival of colon cancer patients. The ability of 1,25D₃ to interfere with Wnt signaling and to ameliorate inflammation is likely to contribute to its anticancer activity.