Kumara HS, Myers EA, Herath SA, Jang JH, Njoh L, Yan X, Kirchoff D, Cekic V, Luchtefeld M, Whelan RL. Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection. World J Gastrointest Oncol 2014; 6(10): 413-419 [PMID: 25320658 DOI: 10.4251/wjgo.v6.i10.413]
Corresponding Author of This Article
Richard L Whelan, MD, Professor of Surgery, Chief, Colon and Rectal Surgery, Chief, Surgical Oncology, Department of Surgery, College of Physicians and Surgeons, Columbia University, 116th St and Broadway, New York, NY 10032, United States. rwhelan@chpnet.org
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Oct 15, 2014; 6(10): 413-419 Published online Oct 15, 2014. doi: 10.4251/wjgo.v6.i10.413
Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection
HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Martin Luchtefeld, Richard L Whelan
HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States
Martin Luchtefeld, Division of Colon and Rectal Surgery, Ferguson Clinic, Grand Rapids, MI 49546, United States
Richard L Whelan, Icahn School of Medicine at-Mount Sinai, New York, NY 10029, United States
Richard L Whelan, Surgical Oncology, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States
Author contributions: Shantha Kumara HMC contributed to the conception, design, sample processing, analysis and interpretation of data, revision of the articles, final approval of article; Myers EA contributed to the manuscript writing, collection of human material and clinical data, final approval of article; Herath SAC and Yan X contributed to the design, human sample collection, processing, analysis and interpretation of data, final approval of article; Jang JH and Kirchoff D contributed to the collection of human material and clinical data, final approval of article; Njoh L contributed to the statistical analysis, interpretation of data, final approval of article; Cekic V and Luchtefeld M contributed to the collection of human material and clinical data, final approval of article; Whelan RL contributed to the conception, design, interpretation of data, critical revision of the article and final approval of article.
Correspondence to: Richard L Whelan, MD, Professor of Surgery, Chief, Colon and Rectal Surgery, Chief, Surgical Oncology, Department of Surgery, College of Physicians and Surgeons, Columbia University, 116th St and Broadway, New York, NY 10032, United States. rwhelan@chpnet.org
Telephone: +1-212-5238172 Fax: +1-212-5238857
Received: April 30, 2014 Revised: August 20, 2014 Accepted: September 16, 2014 Published online: October 15, 2014 Processing time: 173 Days and 2 Hours
Core Tip
Core tip: In our past published studied we have shown that plasma levels of the pro-angiogenic proteins, vascular endothelial growth factor, angiopoietin-2, placental growth factor, and soluble vascular adhesion molecule-1, are significantly elevated for 2-4 wk following minimally invasive colorectal resection for colorectal cancer (CRC). Additionally, we also showed that postoperative plasma from cancer patients stimulates in vitro endothelial cell proliferation, migration, and invasion, all of which are critical steps in angiogenesis. In this manuscript we are presenting data to show that plasma Monocyte chemotactic protein-1 (MCP-1), a pro-angiogenic protein, in CRC patients remain elevated for month after MICR. Furthermore, we are also showing that the median preoperative plasma level of MCP-1 is significantly higher in the CRC patients than in the BEN group.
