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World J Gastrointest Oncol. Jul 15, 2013; 5(7): 159-170
Published online Jul 15, 2013. doi: 10.4251/wjgo.v5.i7.159
Pathological aspects of so called "hilar cholangiocarcinoma"
Víctor M Castellano-Megías, Carolina Ibarrola-de Andrés, Francisco Colina-Ruizdelgado
Víctor M Castellano-Megías, Department of Pathology, Hospital Universitario de Fuenlabrada, 28041 Madrid, Spain.
Carolina Ibarrola-de Andrés, Francisco Colina-Ruizdelgado, Department of Pathology, Hospital Universitario “12 de Octubre”, 28041 Madrid, Spain.
Author contributions: Castellano-Megías VM, Ibarrola-de Andrés C and Colina-Ruizdelgado F contributed equally to this work.
Correspondence to: Francisco Colina-Ruizdelgado, Chief, Department of Pathology, Hospital Universitario “12 de Octubre”, Avenida de Córdoba, s/n, 28041 Madrid, Spain. fcolina.hdoc@salud.madrid.org
Telephone: +34-913-908275 Fax: +34-913-908462
Received: December 12, 2012
Revised: April 24, 2013
Accepted: May 18, 2013
Published online: July 15, 2013
Core Tip

Core tip: The controversy regarding the definition of hilar and perihilar cholangiocarcinoma (CC) is addressed. The authors review the main pathological features (gross and microscopic findings, immunophenotype) of hilar CC, including rare histological variants as well as precursor lesions (biliary intraepithelial neoplasia and intraductal papillary neoplasm of the biliary tract). Considerations regarding staging and other histological prognostic factors are also included. The authors also provide a series of 29 cases of resected hilar CC.