Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2025; 17(7): 108455
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.108455
Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk
Bing Chen, Jun Chen, Zhi-Tao Chen, Zhang-Peng Feng, Han-Bei Lv, Guo-Ping Jiang
Bing Chen, Zhang-Peng Feng, Han-Bei Lv, School of Medicine, Zhejiang Chinese Medical University, Hangzhou 310022, Zhejiang Province, China
Jun Chen, Department of General Surgery, The Second People's Hospital of Guizhou Province, Hangzhou 310022, Zhejiang Province, China
Zhi-Tao Chen, Guo-Ping Jiang, Department of Hepatobiliary Surgery, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou 310022, Zhejiang Province, China
Author contributions: Jiang GP interpreted the study design; Chen ZT and Chen B downloaded data, performed statistical analysis and drafted the manuscript; Chen J, Lv HB and Feng ZP performed data analysis and revised manuscript; Chen ZT, Chen B, and Jiang GP helped revised our manuscript; All authors agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.
Supported by National Key Research and Development Program of China, No. 2021YFA1301104.
Institutional review board statement: This study is based entirely on publicly available, de-identified summary-level genome-wide association study (GWAS) data. Therefore, ethical approval and informed consent were not required. All original studies from which the GWAS data were obtained had received ethical approval from their respective institutional review boards, and participants had provided informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and analyzed in the present study are available from the corresponding authors on reasonable request. The datasets generated and/or analyzed during the current study are available in GWAS (https://gwas.mrcieu.ac.uk/) database.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Ping Jiang, PhD, Professor, Associate Chief Physician, Department of Hepatobiliary Surgery, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, No. 848 Dongxin Road, Hangzhou 310022, Zhejiang Province, China. guoping.jiang@shulan.com
Received: April 14, 2025
Revised: April 30, 2025
Accepted: June 16, 2025
Published online: July 15, 2025
Processing time: 90 Days and 17.7 Hours
Core Tip

Core Tip: This study investigates the causal role of inflammatory factors in the risk of intrahepatic cholangiocarcinoma (ICC) using Mendelian randomization and Bayesian weighted Mendelian randomization analyses. Elevated levels of artemin and matrix metalloproteinase-10 were significantly associated with increased ICC risk, suggesting their potential as risk factors and therapeutic targeting. These results highlight the crucial role of inflammatory factors within the tumor microenvironment in ICC development, offering new insights for targeted interventions.