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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2025; 17(7): 107399
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.107399
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.107399
Predictive value of neutrophil-to-lymphocyte ratio combined with carcinoembryonic antigen in postoperative adjuvant chemotherapy after gastric cancer surgery
Yuan-Zheng Zhao, Jia-Qi Han, Kai-Yu He, Department of Clinical Medicine, Fenyang College Shanxi Medical University, Lüliang 030500, Shanxi Province, China
Xin-Ran Zhao, Department of Optometry and Ophthalmology, Fenyang College Shanxi Medical University, Lüliang 030500, Shanxi Province, China
Zi-Yuan Wang, Department of Medical Laboratory, Fenyang College Shanxi Medical University, Lüliang 030500, Shanxi Province, China
Yong-Sheng Duan, Department of Medical Imaging, Fenyang College Shanxi Medical University, Lüliang 030500, Shanxi Province, China
Hong-Xia Lu, Department of Gastroenterology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, Shanxi Province, China
Author contributions: Lu HX provided research ideas and resources; Zhao YZ collected data and wrote the article and completed the visualization of the research; Han JQ, Zhao XR, Wang ZY, He KY, and Duan YS collected data. All authors have read and approve the final manuscript.
Institutional review board statement: The research was examined and approved by the Ethics Committee of Shanxi Cancer Hospital (Ethics number: KY 2024131).
Informed consent statement: Due to the retrospective observational nature of this study, there was no intervention in the patient's diagnosis and treatment process. Therefore, the Ethics Committee of Shanxi Province approved the waiver of the formal consent that patients provided prior to hospitalization.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: All data from this study can be obtained by email from the corresponding author or first author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Xia Lu, Chief Physician, Full Professor, Head, Department of Gastroenterology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3 Zhigong New Street, Xinghualing District, Taiyuan 030013, Shanxi Province, China. luhongxia@sxmu.edu.cn
Received: March 23, 2025
Revised: April 22, 2025
Accepted: June 12, 2025
Published online: July 15, 2025
Processing time: 114 Days and 3.4 Hours
Revised: April 22, 2025
Accepted: June 12, 2025
Published online: July 15, 2025
Processing time: 114 Days and 3.4 Hours
Core Tip
Core Tip: This investigation conducted a retrospective analysis on a cohort of gastric cancer patients, revealing a 32% disparity in therapeutic efficacy of postoperative adjuvant chemotherapy across distinct neutrophil-to-lymphocyte ratio (NLR)-carcinoembryonic antigen (CEA) stratification groups. Utilizing a stratified approach based on adjuvant chemo