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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2025; 17(7): 106701
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.106701
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.106701
Adult pancreatoblastoma: Systematic review of the literature and case report of a young adult patient
Jacob T Harris, Internal Medicine, HonorHealth Thompson Peak Medical Center, Scottsdale, AZ 85255, United States
Steve Gurley, Department of Pathology, HonorHealth Osborn Medical Center, Scottsdale, AZ 85251, United States
Erkut Borazanci, Department of Oncology, HonorHealth Research Institute, Scottsdale, AZ 85258, United States
Author contributions: Harris JT performed the research and wrote the manuscript; Harris JT and Borazanci E designed the research; Harris JT, Gurley S, and Borazanci E analyzed the data and edited the manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Honor Health Foundation, Michael and Mary Ellen Francis; and the Seena Magowitz Foundation.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jacob T Harris, MD, Internal Medicine, HonorHealth Thompson Peak Medical Center, 7400 E Thompson Peak Parkway, Scottsdale, AZ 85255, United States. jacharris@honorhealth.com
Received: March 5, 2025
Revised: April 30, 2025
Accepted: June 16, 2025
Published online: July 15, 2025
Processing time: 131 Days and 1.4 Hours
Revised: April 30, 2025
Accepted: June 16, 2025
Published online: July 15, 2025
Processing time: 131 Days and 1.4 Hours
Core Tip
Core Tip: Pancreatoblastoma is exceedingly rare in the adolescent/adult population. This is a systematic review of all the 89 available cases in the literature as well as a case presentation. Notable results of this study include: (1) Common histologic features of acinar groups, squamous corpuscles/nests, cytokeratin, chromogranin, trypsin, chymotrypsin, and synaptophysin; (2) Common genetic features of adenomatous polyposis coli, B-cell lymphoma/leukemia 10, catenin beta 1, and Wnt/beta-catenin mutations; and (3) Chemotherapeutic regimens including cisplatin, carboplatin, doxorubicin, 5 fluorouracil, mitomycin, bleomycin, gemcitabine, and vindesine. Future therapies should focus on targeting the Wnt pathway.