Role of myosin heavy chain 9 in gastrointestinal tumorigenesis: A comprehensive review

doi:10.4251/wjgo.v17.i6.106617

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Jun 15, 2025; 17(6): 106617
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.106617

Role of myosin heavy chain 9 in gastrointestinal tumorigenesis: A comprehensive review

Xue-Fan Zeng, Yi-Wei Wang, Yao Ou, Ling Liu

Xue-Fan Zeng, Yao Ou, Ling Liu, Chongqing Medical University, Chongqing 400016, China

Yi-Wei Wang, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China

Co-first authors: Xue-Fan Zeng and Yi-Wei Wang.

Author contributions: Zeng XF and Wang YW contributed equally to this manuscript as co-first authors. Zeng XF and Liu L contributed to conception and design of this study; Zeng XF, Wang YW, and Ou Y participated in manuscript drafting. All the authors reviewed and critically revised the manuscript, and approved the final version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Xue-Fan Zeng, Chongqing Medical University, No. 21 Middle University Town Road Chongqing, Chongqing 400016, China. zxfcqmu@163.com

Received: March 3, 2025
Revised: March 28, 2025
Accepted: May 6, 2025
Published online: June 15, 2025
Processing time: 103 Days and 2.7 Hours

Core Tip

Core Tip: This review delves into the multifaceted role of myosin heavy chain 9 (MYH9) in gastrointestinal tumors. MYH9 is highly expressed in esophageal, gastric, and colorectal cancers, and is closely associated with tumor cell proliferation, invasion, metastasis, and chemoresistance. It also promotes tumor progression by regulating signaling pathways such as the phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin axis. Moreover, MYH9 shows potential as a prognostic biomarker and therapeutic target, offering new directions for improving patient outcomes.